Xanthone from Swertia chirata exerts chemotherapeutic potential against colon carcinoma

被引：3
|
作者：
Barua, Atish [1 ]
Choudhury, Pritha [1 ]
Nag, Niraj [2 ]
Nath, Anirban [3 ]
Kundagrami, Sabyasachi [3 ]
Pal, Amit [2 ]
Panda, Chinmay Kumar [4 ]
Saha, Prosenjit [1 ]
机构：
[1] Chittaranjan Natl Canc Inst, Dept Canc Chemoprevent, 37 SP Mukherjee Rd, Kolkata 700026, India
[2] Natl Inst Cholera & Enter Dis, Div Pathophysiol, P-33 CIT Rd,Scheme XM, Kolkata 700010, India
[3] Univ Calcutta, Dept Genet & Plant Breeding, Kolkata 700073, India
[4] Chittaranjan Natl Canc Inst, Dept Oncogene Regulat, 37 SP Mukherjee Rd, Kolkata 700026, India
来源：
CURRENT SCIENCE | 2022年 / 122卷 / 01期
关键词：
Apoptosis; chemosensitization; colon cancer; reactive oxygen species; Swertia chirata; CANCER; ROS;
D O I：
10.18520/cs/v122/i1/47-55
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The present study examines whether 1,5,8-tri-hydroxy3-methoxy xanthone (TMX) isolated from Swertia chirata could restrict colon cancer cells by downregulating proliferation and inducing apoptosis. The chemotherapeutic activity of TMX was evaluated in several colon cancer and normal cell lines using in vitro assays like annexin V/PI staining, JC10 assay, intracellular reactive oxygen species (ROS) level determination by dicholorofluorescein di-acetate (DCFH-DA). The present study revealed that TMX from S. chirata could effectively inhibit proliferation of metastatic colon cancer cell lines. The chemotherapeutic potential of TMX against metastatic colon cancer cell lines was achieved by downregulating several critical regulatory genes enabling the suppression of the proliferative potential of colon cancer cells and driving them towards apoptosis in a ROS dependent manner. In addition, TMX showed chemosensitization potential in colon cancer cell lines.
引用
收藏
页码：47 / 55
页数：9
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