An expeditious synthesis of 3′-α-carboxymethyl-2′-O-methyl ribonucleosides

被引：13
|
作者：
von Matt, P
Lochmann, T
Kesselring, R
Altmann, KH
机构：
[1] Novartis Pharmaceut, Summit, NJ 07901 USA
[2] Novartis Pharma AG, CH-4002 Basel, Switzerland
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 10期
关键词：
D O I：
10.1016/S0040-4039(99)00147-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3'-alpha-Carboxymethyl-2'-O-methyl ribonucleosides, which are important building blocks for the construction of high affinity amide modified antisense oligonucleotides, have been synthesized from the corresponding 2'-O-methyl ribonucleosides via catalytic hydrogenation of their 3'-deoxy 3'-methoxycarbonyl-methylidene derivatives. Reduction of the olefinic double bond proceeds in good to excellent yields and with alpha/beta-product ratios > 9/1. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1873 / 1876
页数：4
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