Gut Microbial Profile Is Associated With the Severity of Social Impairment and IQ Performance in Children With Autism Spectrum Disorder

被引:19
|
作者
Chen, Zilin [1 ,2 ]
Shi, Kai [3 ]
Liu, Xin [1 ,2 ]
Dai, Yuan [1 ,2 ]
Liu, Yuqi [1 ,2 ]
Zhang, Lingli [1 ,2 ]
Du, Xiujuan [1 ,2 ]
Zhu, Tailin [1 ,2 ]
Yu, Juehua [4 ]
Fang, Shuanfeng [5 ]
Li, Fei [1 ,2 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Dev & Behav Pediat & Child Primary Care, Behav Res Unit, Shanghai Inst Pediat Res,Sch Med, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, MOE Shanghai Key Lab Childrens Environm Hlth, Xinhua Hosp, Sch Med, Shanghai, Peoples R China
[3] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China
[4] Kunming Med Univ, Ctr Expt Studies & Res, Affiliated Hosp 1, Kunming, Peoples R China
[5] Zhengzhou Univ, Dept Child Hlth Care, Childrens Hosp, Zhengzhou, Peoples R China
来源
FRONTIERS IN PSYCHIATRY | 2021年 / 12卷
基金
中国国家自然科学基金;
关键词
autism; gut microbiota; 16S rRNA; developmental delay; intellectual disability; intelligence quotient; DISABILITIES MONITORING NETWORK; AGED; 8; YEARS; UNITED-STATES; 11; SITES; SYMPTOMS; PREVALENCE; BEHAVIOR;
D O I
10.3389/fpsyt.2021.789864
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background and Objective: Autism spectrum disorder (ASD) refers to a heterogeneous set of neurodevelopmental disorders with diverse symptom severity and comorbidities. Although alterations in gut microbiota have been reported in individuals with ASD, it remains unclear whether certain microbial pattern is linked to specific symptom or comorbidity in ASD. We aimed to investigate the associations between gut microbiota and the severity of social impairment and cognitive functioning in children with ASD.Methods: A total of 261 age-matched children, including 138 children diagnosed with ASD, 63 with developmental delay or intellectual disability (DD/ID), and 60 typically developing (TD) children, were enrolled from the Shanghai Xinhua Registry. The children with ASD were further classified into two subgroups: 76 children diagnosed with ASD and developmental disorder (ASD+DD) and 62 with ASD only (ASD-only). The gut microbiome of all children was profiled and evaluated by 16S ribosomal RNA sequencing.Results: The gut microbial analyses demonstrated an altered microbial community structure in children with ASD. The alpha diversity indices of the ASD+DD and ASD-only subgroups were significantly lower than the DD/ID or TD groups. At the genus level, we observed a decrease in the relative abundance of Prevotella. Simultaneously, Bacteroides and Faecalibacterium were significantly increased in ASD compared with DD/ID and TD participants. There was a clear correlation between alpha diversity and the Childhood Autism Rating Scale (CARS) total score for all participants, and this correlation was independent of IQ performance. Similar correlations with the CARS total score were observed for genera Bacteroides, Faecalibacterium, and Oscillospira. However, there was no single genus significantly associated with IQ in all participants.Conclusions: Specific alterations in bacterial taxonomic composition and associations with the severity of social impairment and IQ performance were observed in children with ASD or ASD subgroups, when compared with DD/ID or TD groups. These results illustrate that gut microbiota may serve as a promising biomarker for ASD symptoms. Nevertheless, further investigations are warranted.
引用
收藏
页数:13
相关论文
共 50 条
  • [41] Gut Microbial Dysbiosis in Indian Children with Autism Spectrum Disorders
    Pulikkan, Joby
    Maji, Abhijit
    Dhakan, Darshan Bharat
    Saxena, Rituja
    Mohan, Binoop
    Anto, Milu Maria
    Agarwal, Neeti
    Grace, Tony
    Sharma, Vineet K.
    MICROBIAL ECOLOGY, 2018, 76 (04) : 1102 - 1114
  • [42] Gut Microbial Dysbiosis in Indian Children with Autism Spectrum Disorders
    Joby Pulikkan
    Abhijit Maji
    Darshan Bharat Dhakan
    Rituja Saxena
    Binoop Mohan
    Milu Maria Anto
    Neeti Agarwal
    Tony Grace
    Vineet K. Sharma
    Microbial Ecology, 2018, 76 : 1102 - 1114
  • [43] Urinary Metabolomic Profile in Children with Autism Spectrum Disorder
    Osredkar, Josko
    Kumer, Kristina
    Godnov, Uros
    Vrhovsek, Maja Jekovec
    Vidova, Veronika
    Price, Elliott James
    Javornik, Tara
    Avgustin, Gorazd
    Fabjan, Teja
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (05)
  • [44] ADHD severity as a predictor of cognitive task performance in children with Autism Spectrum Disorder (ASD)
    Mansour, Rosleen
    Ward, Anthony R.
    Lane, David M.
    Loveland, Katherine A.
    Aman, Michael G.
    Jerger, Susan
    Schachar, Russell J.
    Pearson, Deborah A.
    RESEARCH IN DEVELOPMENTAL DISABILITIES, 2021, 111
  • [45] Brief Report: The Factors Associated with Social Cognition in Children with Autism Spectrum Disorder
    Santini, Anysa
    Bullen, Jennifer C.
    Zajic, Matthew C.
    McIntyre, Nancy
    Mundy, Peter
    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2024, 54 (10) : 3964 - 3970
  • [46] Improved Social Communication Abilities and Reduced Autism Severity in Children with Autism Spectrum Disorder and Highly Sensitive Mothers
    Marquez, Carla
    Solis-Vivanco, Rodolfo
    Schilmann, Astrid
    Nicolini, Humberto
    PARENTING-SCIENCE AND PRACTICE, 2021, 21 (01): : 47 - 54
  • [47] Subdimensions of social-communication impairment in autism spectrum disorder
    Bishop, Somer L.
    Havdahl, Karoline Alexandra
    Huerta, Marisela
    Lord, Catherine
    JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2016, 57 (08) : 909 - 916
  • [48] The role of executive functions in social impairment in Autism Spectrum Disorder
    Leung, Rachel C.
    Vogan, Vanessa M.
    Powell, Tamara L.
    Anagnostou, Evdokia
    Taylor, Margot J.
    CHILD NEUROPSYCHOLOGY, 2016, 22 (03) : 336 - 344
  • [49] Alterations of Gut Microbiota among Children with Autism Spectrum Disorder
    Nakazawa-Miklasevica, M.
    Daneberga, Z.
    Murmane, D.
    Kroica, J.
    Cupane, L.
    Isarova, D.
    Berga-Svitina, E.
    Masinska, M.
    Miklasevics, E.
    MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY, 2021, 36 (SUPPL 1) : S29 - S36
  • [50] Alterations of Gut Microbiota among Children with Autism Spectrum Disorder
    M. Nakazawa-Miklasevica
    Z. Daneberga
    D. Murmane
    J. Kroica
    L. Cupane
    D. Isarova
    E. Berga-Svitina
    M. Masinska
    E. Miklasevics
    Molecular Genetics, Microbiology and Virology, 2021, 36 : S29 - S36