Development of a bone defect model for testing injectable bone substitutes and evaluation of a calcium phosphate cement

New percutaneous filling techniques are beginning to be used bl bone tumor pathology The purpose of this study was to develop a reproducible model for testing new injectable bone substitutes. A closed cancellous bone defect was created in the distal femoral condyles of rabbit. Bone defect was filled by a percutaneous injection. Several situations were tested I spontaneous evolution of unfilled cavities, evolution of cavities filled either with a conventional orthopedic cement (PMMA), either with a mixed collagen-hydroxyapatite material, either with a biomaterial derived from the vegetal protein zein, either with a calcium phosphate cement brushite type. The new bone formation was quantified in the defect for each group in which several delays were tested. A bone defect of reproducible size was obtained consistently A partial bone formation was observed in the unfilled group. The best bone formation rare Iras obtained in the phosphate cement group This model showed the interest of injectable biomaterials and more precisely the interest of the phosphate calcium cements as brushite.