Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients

被引：6
|
作者：
Gervasini, Guillermo [1 ]
Garcia-Pino, Guadalupe [1 ,2 ]
Mota-Zamorano, Sonia [1 ]
Luna, Enrique [3 ]
Garcia-Cerrada, Montserrat [4 ]
Angeles Tormo, Maria [5 ]
Jose Cubero, Juan [3 ]
机构：
[1] Univ Extremadura, Med Sch, Dept Med & Surg Therapeut, Badajoz, Spain
[2] Hosp Zafra, Serv Nephrol, Extremadura, Spain
[3] Univ Hosp, Serv Nephrol, Badajoz, Spain
[4] Don Benito Villanueva Hosp, Serv Clin Anal, Villanueva De La Serena, Spain
[5] Univ Extremadura, Med Sch, Dept Physiol, Badajoz, Spain
来源：
PHARMACOGENOMICS JOURNAL | 2020年 / 20卷 / 03期
关键词：
CORONARY-ARTERY-DISEASE; RECEPTOR GENE; LYS656ASN POLYMORPHISM; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; RISK-FACTORS; RS1501299; RS1137101;
D O I：
10.1038/s41397-019-0128-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 +/- 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for LEPR rs1805094 and ADIPOQ rs1501299 and risk of graft loss were 0.35 (0.16-0.74) p = 0.006 and 2.37 (1.28-4.37) p = 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06-0.62), p = 0.005, and 2.43 (1.08-5.44), p = 0.031 for LEPR rs1805094 and ADIPOQ rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.
引用
收藏
页码：388 / 397
页数：10
相关论文
共 50 条
  • [31] Long-term renal function after pregnancy in renal transplant recipients
    Tanabe, K
    Kobayashi, C
    Takahashi, K
    Sonda, K
    Tokumoto, T
    Ishikawa, N
    Koga, S
    Naito, T
    Kawai, T
    Fuchinoue, S
    Yagisawa, T
    Goya, N
    Nakazawa, H
    Kawaguchi, H
    Ito, K
    Agishi, T
    Toma, H
    Ota, K
    TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) : 1567 - 1568
  • [32] Long-term survival in renal transplant recipients with graft function
    Ojo, AO
    Hanson, JA
    Wolfe, RA
    Leichtman, AB
    Agodoa, LY
    Port, FK
    KIDNEY INTERNATIONAL, 2000, 57 (01) : 307 - 313
  • [33] Hypertension and renal dysfunction in long-term liver transplant recipients
    Gonwa, TA
    LIVER TRANSPLANTATION, 2001, 7 (11) : S22 - S26
  • [34] Prevalence of Vertebral Fractures in Long-Term Renal Transplant Recipients
    Marcen, R.
    Jimenez Alvaro, S.
    Vaamonde, J. C.
    Caballero, C.
    Fernandez-Rodriguez, A.
    Galeano, C.
    Villafruela, J. J.
    Rodriguez-Mendiola, N.
    Teruel, J. L.
    Burgos, J.
    Quereda, C.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 : 425 - 425
  • [35] Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis
    Yusuf, Erlangga
    Ioan-Facsinay, Andreea
    Bijsterbosch, Jessica
    Klein-Wieringa, Inge
    Kwekkeboom, Joanneke
    Slagboom, P. Eline
    Huizinga, Tom W. J.
    Kloppenburg, Margreet
    ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (07) : 1282 - 1284
  • [36] Clinical audit and long-term evaluation of renal transplant recipients
    Short, CD
    Russell, S
    Valentine, A
    TRANSPLANTATION, 2001, 72 (12) : SS94 - SS98
  • [37] Risk of malignancy with long-term immunosuppression in renal transplant recipients
    Agraharkar, ML
    Cinclair, RD
    Kuo, YF
    Daller, JA
    Shahinian, VB
    KIDNEY INTERNATIONAL, 2004, 66 (01) : 383 - 389
  • [38] A long-term study on hyperlipidemia in stable renal transplant recipients
    Tse, KC
    Lam, MF
    Yip, PS
    Li, FK
    Lai, KN
    Chan, TM
    CLINICAL TRANSPLANTATION, 2004, 18 (03) : 274 - 280
  • [39] Effect of ciclosporin on triglyceridemia in long-term renal transplant recipients
    Verzola, A
    Bedani, PL
    Gilli, P
    NEPHRON, 1999, 81 (02): : 240 - 241
  • [40] Association of single nucleotide polymorphisms of adiponectin and leptin genes with breast cancer
    Geriki, Sarvari
    Bitla, Aparna R.
    SrinivasaRao, P. V. L. N.
    Hulikal, Narendra
    Yootla, Mutheeswaraiah
    Sachan, Alok
    Amancharla Yadagiri, Lakshmi
    Asha, T.
    Manickavasagam, M.
    Kannan, T.
    Kumari, Aruna P.
    MOLECULAR BIOLOGY REPORTS, 2019, 46 (06) : 6287 - 6297
12345