Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients

被引：6
|
作者：
Gervasini, Guillermo [1 ]
Garcia-Pino, Guadalupe [1 ,2 ]
Mota-Zamorano, Sonia [1 ]
Luna, Enrique [3 ]
Garcia-Cerrada, Montserrat [4 ]
Angeles Tormo, Maria [5 ]
Jose Cubero, Juan [3 ]
机构：
[1] Univ Extremadura, Med Sch, Dept Med & Surg Therapeut, Badajoz, Spain
[2] Hosp Zafra, Serv Nephrol, Extremadura, Spain
[3] Univ Hosp, Serv Nephrol, Badajoz, Spain
[4] Don Benito Villanueva Hosp, Serv Clin Anal, Villanueva De La Serena, Spain
[5] Univ Extremadura, Med Sch, Dept Physiol, Badajoz, Spain
来源：
PHARMACOGENOMICS JOURNAL | 2020年 / 20卷 / 03期
关键词：
CORONARY-ARTERY-DISEASE; RECEPTOR GENE; LYS656ASN POLYMORPHISM; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; RISK-FACTORS; RS1501299; RS1137101;
D O I：
10.1038/s41397-019-0128-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 +/- 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for LEPR rs1805094 and ADIPOQ rs1501299 and risk of graft loss were 0.35 (0.16-0.74) p = 0.006 and 2.37 (1.28-4.37) p = 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06-0.62), p = 0.005, and 2.43 (1.08-5.44), p = 0.031 for LEPR rs1805094 and ADIPOQ rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.
引用
收藏
页码：388 / 397
页数：10
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