Methadone determination in puparia and its effect on the development of Lucilia sericata (Diptera, Calliphoridae)

被引：20

作者：

Gosselin, Matthias ^{[1
,2
]}

Di Fazio, Vincent ^{[1
]}

Wille, Sarah M. R. ^{[1
]}

Fernandez, Maria del Mar Ramirez ^{[1
]}

Samyn, Nele ^{[1
]}

Bourel, Benoit ^{[3
,4
,5
]}

Rasmont, Pierre ^{[2
]}

机构：

[1] Natl Inst Criminalist & Criminol, Toxicol Lab, B-1120 Brussels, Belgium

[2] Univ Mons, Zool Lab, B-7000 Mons, Belgium

[3] Univ Lille Nord France, F-59000 Lille, France

[4] UCLille, FLST, Lab Environm & Sante, F-59000 Lille, France

[5] UDSL, IML, F-59000 Lille, France

来源：

FORENSIC SCIENCE INTERNATIONAL | 2011年 / 209卷 / 1-3期

关键词：

UPLC-MS/MS; Empty puparial case; Methadone; Blowflies; Entomotoxicology; DECOMPOSING TISSUES; RABBIT CARCASSES; DRUG LEVELS; LARVAE; VICINA; ACCUMULATION; ELIMINATION; MORPHINE; SARCOPHAGIDAE; AMITRIPTYLINE;

D O I：

10.1016/j.forsciint.2011.01.020

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

This paper describes a sensitive UPLC-MS/MS method for quantification of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in single empty puparial case of Lucilia sericata. Larvae were reared on substrates spiked with different concentrations of methadone (0-4 mu g/g). Methadone was quantified in puparia reared on high concentrated substrates (0.8-4 mu g/g). The major metabolite of methadone (EDDP) was not detected, confirming rapid elimination of metabolites by the larvae before pupation. The effects of methadone on the development of L. sericata were also investigated. No effect on sex ratio was detected. A significant difference was calculated for emerged adults but no trends could be observed. Concerning the developmental curve, a significant difference was observed between control and high methadone concentrations using the Kolmogorov-Smirnov test. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：154 / 159

页数：6

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