Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats

被引：8

作者：

Hwang, Seung-Jun ^{[1
]}

Huh, Youngbuhm ^{[2
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Anat & Cell Biol, Seoul 138736, South Korea

[2] Kyung Hee Univ, Dept Anat & Neurobiol, Inst Biomed Sci, Sch Med, Seoul 130701, South Korea

来源：

JOURNAL OF MOLECULAR HISTOLOGY | 2010年 / 41卷 / 2-3期

关键词：

NADPH diaphorase; Nitric oxide synthase; 3-Nitrotyrosine; Aged rats; Lateral geniculate nucleus; NADPH-DIAPHORASE; CEREBRAL-CORTEX; TYROSINE NITRATION; ALZHEIMERS-DISEASE; OXIDATIVE DAMAGE; NEURONS; PEROXYNITRITE; BRAIN; PROTEINS; ARGINASE;

D O I：

10.1007/s10735-010-9268-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Age-related changes in nitric oxide production in the visual system have not been well characterized. Therefore, we used staining and image-processing approaches to describe changes in levels of neuronal nitric oxide synthase (nNOS), the NADPH-diaphorase (NADPH-d) histochemical marker, and 3-nitrotyrosine in the lateral geniculate nucleus (LGN) of young and aged rats. The LGN plays an important role in the visual system, as it acts as a visual relay nucleus. Quantitative analysis of NADPH-d-positive and nNOS-immunoreactive neurons revealed significant optical density increases in the dorsal LGN and ventral LGN of aged rats; however, no significant changes were observed in the number of neurons with age. 3-Nitrotyrosine immunoreactivity was increased in the dorsal LGN and ventral LGN of aged rats. These results indicate that increased nitric oxide production and peroxynitrite may be associated with alterations in visual function during aging.

引用

页码：129 / 135

页数：7

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