Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner

被引：19
|
作者：
Chu, Guanghui [1 ]
Qi, Shengbin [1 ]
Yang, Guodong [2 ]
Dou, Kefeng [3 ]
Du, Jianjun [1 ]
Lu, Zifan [2 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Dept Hepatobiliary Surg, Xijing Hosp, Xian 710032, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2012年 / 359卷 / 1-2期
基金：
美国国家科学基金会;
关键词：
GDDR; TFF1; Gastric cancer; Cell cycle; Proliferation; HELICOBACTER-PYLORI INFECTION; PANCREATIC SPASMOLYTIC POLYPEPTIDE; TREFOIL PROTEIN; INTESTINAL METAPLASIA; CARCINOGENESIS; EXPRESSION; CARCINOMA; DOMAIN; ASSOCIATION; SUPPRESSOR;
D O I：
10.1007/s11010-011-1030-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner.
引用
收藏
页码：369 / 374
页数：6
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