Foxo1 and Foxo3 help Foxp3

被引:30
|
作者
Ohkura, Naganari [1 ,2 ]
Sakaguchi, Shimon [1 ,2 ]
机构
[1] Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Dept Expt Immunol, Suita, Osaka 5650871, Japan
[2] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan
关键词
REGULATORY T-CELLS; EXPRESSION; DIFFERENTIATION; RECEPTOR; MTOR; AKT;
D O I
10.1016/j.immuni.2010.12.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this issue of Immunity, Kerdiles et al. (2010) report that Foxo transcription factors are essential for the development and function of Foxp3-expressing regulatory T (Treg) cells via controlling the expression of genes associated with Treg cell function.
引用
收藏
页码:835 / 837
页数:3
相关论文
共 50 条
  • [41] Inhibition of FOXO1/3 Promotes Vascular Calcification
    Deng, Liang
    Huang, Lu
    Sun, Yong
    Heath, Jack M.
    Wu, Hui
    Chen, Yabing
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015, 35 (01) : 175 - 183
  • [42] PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
    Merkenschlager, Matthias
    von Boehmer, Harald
    JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (07): : 1347 - 1350
  • [43] Role of FoxO1 in Acne and Effect of Isotretinoin on FoxO1 Expression
    Kamboj, Parul
    Khullar, Geeti
    Handa, Sanjeev
    Pal, Arnab
    Saikia, Uma Nahar
    De, Dipankar
    INDIAN DERMATOLOGY ONLINE JOURNAL, 2024, 15 (02) : 252 - 254
  • [44] Truncated FOXO1 DNA-binding domain in Pax3-FOXO1 contributes to Pax3-FOXO1 DNA binding
    Blunt, Endia
    Paul, Manisha
    Nesbit, Jacqueline
    Johanson, Kelly
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [45] Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis
    Xu, Xiaoyuan
    Xu, Xiaohua
    Wang, Xiaoshuang
    Shen, Ling
    PHARMACEUTICAL BIOLOGY, 2023, 61 (01) : 878 - 885
  • [46] Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
    F Wang
    C-H Chan
    K Chen
    X Guan
    H-K Lin
    Q Tong
    Oncogene, 2012, 31 : 1546 - 1557
  • [47] Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
    Wang, F.
    Chan, C-H
    Chen, K.
    Guan, X.
    Lin, H-K
    Tong, Q.
    ONCOGENE, 2012, 31 (12) : 1546 - 1557
  • [48] Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1
    Bothur, Evita
    Raifer, Hartmann
    Haftmann, Claudia
    Stittrich, Anna-Barbara
    Bruestle, Anne
    Brenner, Dirk
    Bollig, Nadine
    Bieringer, Maria
    Kang, Chol-Ho
    Reinhard, Katharina
    Camara, Baerbel
    Huber, Magdalena
    Visekruna, Alexander
    Steinhoff, Ulrich
    Repenning, Antje
    Bauer, Uta-Maria
    Sexl, Veronika
    Radbruch, Andreas
    Sparwasser, Tim
    Mashreghi, Mir-Farzin
    Mak, Tak Wah
    Lohoff, Michael
    NATURE COMMUNICATIONS, 2015, 6
  • [49] Expressions of FOXO1 and FOXO3a in skeletal muscle atrophy associated with neuromuscular diseases
    Ishii, A.
    Ohkoshi, N.
    Tamaoka, A.
    NEUROMUSCULAR DISORDERS, 2008, 18 (9-10) : 789 - 789
  • [50] FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway
    Zhou, Jingyi
    Liao, Wenjuan
    Yang, Jing
    Ma, Ke
    Li, Xue
    Wang, Yachen
    Wang, Donglai
    Wang, Lina
    Zhang, Yu
    Yin, Yuxin
    Zhao, Ying
    Zhu, Wei-Guo
    AUTOPHAGY, 2012, 8 (12) : 1712 - 1723