Synthesis of Poly-Substituted Pyridines via Noble-Metal-Free Cycloaddition of Ketones and Imines

被引：1

作者：

Mao, Yeting ^{[1
]}

Mao, Hong ^{[1
]}

Xu, Jiaojiao ^{[1
]}

Liu, Tianqi ^{[1
]}

Liu, Bingxin ^{[1
]}

Tan, Qitao ^{[1
]}

Ding, Chang-Hua ^{[1
]}

Xu, Bin ^{[1
,2
]}

机构：

[1] Shanghai Univ, Affiliated Nantong Hosp, Shanghai Engn Res Ctr Organ Repair,Dept Chem, Innovat Drug Res Ctr,Peoples Hosp Nantong 6, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2021年 / 16卷 / 23期

基金：

中国国家自然科学基金;

关键词：

substituted pyridine; formal [4+2] cycloaddition; ketone; imine; noble-metal-free; HIGHLY FUNCTIONALIZED PYRIDINES; BOND-CLEAVAGE; ALPHA; BETA-UNSATURATED KETOXIMES; REGIOSELECTIVE SYNTHESIS; CATALYZED CYCLIZATION; TERMINAL ALKYNES; OXIMES; CONSTRUCTION; ISOCYANIDES; INHIBITORS;

D O I：

10.1002/asia.202100983

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An eco-friendly and noble-metal-free formal [4+2] cycloaddition reaction was developed for the efficient synthesis of biologically interesting poly-substituted pyridines from easily available ketones and imines, whereby two sequential C-C bonds are formed. The given approach features a unique synthetic strategy of imines and ketones with wide substrate scope, good functional group tolerance, mild conditions and operational simplicity, which represents a more direct pathway to synthesize poly-substituted pyridines than traditional methods.

引用

页码：3905 / 3908

页数：4

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