Delivery systems for DNA-binding drugs as gene expression modulators

被引：6
|
作者：
Cortesi, R
Nastruzzi, C
机构：
[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
[2] Dipartimento Chim & Tecnol Farm, I-06100 Perugia, Italy
来源：
DRUG DISCOVERY TODAY | 2001年 / 6卷 / 17期
关键词：
D O I：
10.1016/S1359-6446(01)01893-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Despite the large number of publications describing the synthesis and physicocharacterization of the binding between drugs and DNA, relatively few examine drug delivery systems (DDSs) for these molecules. The aim to find DDSs for DNA-binding drugs (DBDs) was prompted mainly to reduce the toxicity and/or enhance the tumor specificity of systemically administered drugs. With this in mind, we have reviewed the biological effects of some DBDs that are currently used as antitumor drugs and describe a brief selection of DDSs currently in clinical trials or on the market.
引用
收藏
页码：893 / 904
页数：12
相关论文
共 50 条
  • [31] EFFECTS OF DNA-BINDING DRUGS ON T4 DNA-LIGASE
    MONTECUCCO, A
    PEDRALINOY, G
    SPADARI, S
    LESTINGI, M
    CIARROCCHI, G
    BIOCHEMICAL JOURNAL, 1990, 266 (02) : 379 - 384
  • [32] DNA-binding peptide dendrimer for efficient and selective intracellular delivery
    Kam, Antony
    Wong, Clarence Tsun Ting
    Loo, Shining
    Tam, James P.
    FASEB JOURNAL, 2018, 32 (01):
  • [33] Gene-targeted transcriptional silencing by DNA-binding
    Botta, Salvatore
    Marrocco, Elena
    de Prisco, Nicola
    Curion, Fabiola
    Renda, Mario
    Sofia, Martina
    Bacci, Maria Laura
    Gesualdo, Carlo
    Rossi, Settimio
    Simonelli, Francesca
    Surace, Enrico Maria
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [34] ALPHA-FETOPROTEIN GENE DNA-BINDING PROTEINS
    COTE, GJ
    WANG, Z
    CHIU, JF
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 243 (01) : 320 - 324
  • [35] Predicting transcription factor binding motifs from DNA-binding domains, chromatin accessibility and gene expression data
    Zamanighomi, Mahdi
    Lin, Zhixiang
    Wang, Yong
    Jiang, Rui
    Wong, Wing Hung
    NUCLEIC ACIDS RESEARCH, 2017, 45 (10) : 5666 - 5677
  • [36] THE BRACHYURY GENE ENCODES A NOVEL DNA-BINDING PROTEIN
    KISPERT, A
    HERRMANN, BG
    EMBO JOURNAL, 1993, 12 (08): : 3211 - 3220
  • [37] SCREENING OF COMPREHENSIVE EXPRESSION LIBRARIES FOR DNA-BINDING PROTEINS
    TORNOW, J
    SANTANGELO, G
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, : 107 - 107
  • [38] VECTORS FOR THE EXPRESSION AND ANALYSIS OF DNA-BINDING PROTEINS IN YEAST
    BONNER, JJ
    GENE, 1991, 104 (01) : 113 - 118
  • [39] Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene
    Ivanova, Olga
    Braas, Daniel
    Klempnauer, Karl-Heinz
    NUCLEIC ACIDS RESEARCH, 2007, 35 (21) : 7237 - 7247
  • [40] DNA-BINDING INTERFACE OF THE GENE-5 DNA UNWINDING PROTEIN
    MCPHERSON, A
    WANG, AHJ
    JURNAK, FA
    MOLINEUX, T
    RICH, A
    JOURNAL OF SUPRAMOLECULAR STRUCTURE, 1979, : 106 - 106
12345