Regulation of gene expression in a type II restriction-modification system

被引：11
|
作者：
Nagornykh, M. O. [1 ]
Bogdanova, E. S. [1 ,3 ]
Protsenko, A. S. [1 ]
Solonin, A. S. [1 ]
Zakharova, M. V. [1 ]
Severinov, K. V. [2 ,3 ]
机构：
[1] Russian Acad Sci, Inst Biochem & Physiol Microorganisms, Pushchino 142290, Russia
[2] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
[3] State Univ New Jersy, Waksman Inst, Piscataway, NJ 08854 USA
来源：
RUSSIAN JOURNAL OF GENETICS | 2008年 / 44卷 / 05期
关键词：
D O I：
10.1134/S1022795408050037
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Type II restriction-modification systems are comprised of a restriction endonuclease and methyltransferase. The enzymes are coded by individual genes and recognize the same DNA sequence. Endonuclease makes a double-stranded break in the recognition site, and methyltransferase covalently modifies DNA bases within the recognition site, thereby preventing cleavage by the endonuclease. The concerted action of these enzymes plays the role of a primitive immune system and protects the bacterial host cell from invasion by foreign (for example, viral) DNA. However, uncontrolled expression of restriction-modification system genes can result in the death of a bacterial host cell because of endonuclease cleavage of the host DNA. In the present review, data on the regulation of expression of the type II restriction-modification enzymes genes are discussed.
引用
收藏
页码：523 / 532
页数：10
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