Design and synthesis of benzimidazole derivatives as antimycobacterial agents

被引：3

作者：

Sindhu, Gagandeep ^{[1
]}

Kholiya, Rohit ^{[1
]}

Kidwai, Saqib ^{[2
]}

Singh, Padam ^{[2
]}

Singh, Ramandeep ^{[2
]}

Rawat, Diwan S. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, New Delhi 110007, India

[2] Translat Hlth Sci & Technol Inst, TB Res Lab, Faridabad, Haryana, India

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2022年 / 36卷 / 09期

关键词：

antituberculosis; benzimidazole; H(37)Rv strain; isoniazid; Mycobacterium tuberculosis; DRUG-RESISTANT TUBERCULOSIS; MULTIDRUG-RESISTANT; IN-VITRO; ANTITUBERCULOSIS; INHIBITORS;

D O I：

10.1002/jbt.23123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 2,5-disubstituted benzimidazole derivatives was synthesized with the aim to identify compounds with potent anti-TB activity. All the compounds were screened in vitro against cultured Mycobacterium tuberculosis H(37)Rv strain and found to be exhibiting MIC99 values in the range of 0.195-100 mu M. Out of 43 synthesized compounds, two compounds 11h and 13e showed better anti-TB activity than the reference drug isoniazid.

引用

页数：7

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