Next-generation sequencing: hype and hope for development of personalized radiation therapy?

被引：7

作者：

Tinhofer, Ingeborg ^{[1
,2
,3
]}

Niehr, Franziska ^{[1
,2
,3
]}

Konschak, Robert ^{[1
,2
,3
]}

Liebs, Sandra ^{[2
,3
]}

Munz, Matthias ^{[4
]}

Stenzinger, Albrecht ^{[5
,6
]}

Weichert, Wilko ^{[5
,6
]}

Keilholz, Ulrich ^{[7
]}

Budach, Volker ^{[1
,2
,3
]}

机构：

[1] Charite, Dept Radiooncol & Radiotherapy, Translat Radiat Oncol Res Lab, D-10117 Berlin, Germany

[2] German Canc Res Ctr, Heidelberg, Germany

[3] German Canc Consortium DKTK Partner Site, Heidelberg, Germany

[4] Humboldt Univ, Inst Theoret Biol, Grp Computat Modelling Med, D-10099 Berlin, Germany

[5] Univ Hosp, Inst Pathol, Heidelberg, Germany

[6] Natl Ctr Tumor Dis, Heidelberg, Germany

[7] Charite, Charite Comprehens Canc Ctr, Berlin, Germany

来源：

RADIATION ONCOLOGY | 2015年 / 10卷

关键词：

CIRCULATING TUMOR DNA; DOUBLE-STRAND BREAKS; INTRATUMOR HETEROGENEITY; MUTATIONAL LANDSCAPE; BLOOD-LYMPHOCYTES; CANCER; HEAD; EVOLUTION; REPAIR; RADIOSENSITIVITY;

D O I：

10.1186/s13014-015-0481-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The introduction of next-generation sequencing (NGS) in the field of cancer research has boosted worldwide efforts of genome-wide personalized oncology aiming at identifying predictive biomarkers and novel actionable targets. Despite considerable progress in understanding the molecular biology of distinct cancer entities by the use of this revolutionary technology and despite contemporaneous innovations in drug development, translation of NGS findings into improved concepts for cancer treatment remains a challenge. The aim of this article is to describe shortly the NGS platforms for DNA sequencing and in more detail key achievements and unresolved hurdles. A special focus will be given on potential clinical applications of this innovative technique in the field of radiation oncology.

引用

页数：8

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