Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts

被引：8

作者：

Popov, Sergey A. ^{[1
]}

Kozlova, Lyubov' P. ^{[1
]}

Kornaukhova, Lyubov' M. ^{[1
]}

Shpatov, Alexander V. ^{[1
]}

机构：

[1] Novosibirsk Organ Chem Inst, Acad Lavrentyev Ave 9, Novosibirsk 630090, Russia

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2016年 / 92卷

关键词：

Betulonic acid; Betulin; Birch bark extraction; Extract oxidation; BETULINIC ACID; DERIVATIVES;

D O I：

10.1016/j.indcrop.2016.07.026

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

A bioactive triterpenoid betulonic acid is a valuable synthone for preparation of lupane- and oleanane-type derivatives with a wide spectrum of medical applications. A large-scale, cost-effective, and simple preparation of betulonic acid from birch (Betula pendula) bark is presented herein. The process includes four steps with the acid overall yield of 51% counting on betulin content in the extract and with the acid purity of 90% or more. The process can be employed for batch production of betulonic acid. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：197 / 200

页数：4

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