Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts

被引：8
|
作者：
Popov, Sergey A. [1 ]
Kozlova, Lyubov' P. [1 ]
Kornaukhova, Lyubov' M. [1 ]
Shpatov, Alexander V. [1 ]
机构：
[1] Novosibirsk Organ Chem Inst, Acad Lavrentyev Ave 9, Novosibirsk 630090, Russia
来源：
INDUSTRIAL CROPS AND PRODUCTS | 2016年 / 92卷
关键词：
Betulonic acid; Betulin; Birch bark extraction; Extract oxidation; BETULINIC ACID; DERIVATIVES;
D O I：
10.1016/j.indcrop.2016.07.026
中图分类号：
S2 [农业工程];
学科分类号：
0828 ;
摘要：
A bioactive triterpenoid betulonic acid is a valuable synthone for preparation of lupane- and oleanane-type derivatives with a wide spectrum of medical applications. A large-scale, cost-effective, and simple preparation of betulonic acid from birch (Betula pendula) bark is presented herein. The process includes four steps with the acid overall yield of 51% counting on betulin content in the extract and with the acid purity of 90% or more. The process can be employed for batch production of betulonic acid. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：197 / 200
页数：4
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