Human herpesvirus 8 DNA sequences are present in bone marrow from HIV-negative patients with lymphoproliferative disorders and from healthy donors

被引：4
|
作者：
Azzi, A
Fanci, R
De Santis, R
Ciappi, S
Paci, C
机构：
[1] Univ Florence, Dept Epidemiol & Publ Hlth, Microbiol & Virol Unit, I-50134 Florence, Italy
[2] Univ Florence, Haematol Unit, I-50134 Florence, Italy
[3] Careggi Hosp Florence, Florence, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 01期
关键词：
Kaposi's sarcoma-associated herpesvirus (KSHV); multiple myeloma; monoclonal gammopathy; non-Hodgkins lymphoma; viral persistence;
D O I：
10.1046/j.1365-2141.2001.02702.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bone marrow (BM) from patients affected by multiple myeloma (MM), exhibiting monoclonal gammopathy of undetermined significance (MGUS) or with non-Hodgkin lymphoma (NHL) as well as from healthy donors were investigated for the presence of human herpesvirus-8 (HHV-8) DNA sequences. ORF 26 sequences were detected in 36-56% of the patients and in 29% of the controls. In a few cases, two other HHV-8 DNA sequences were also detected. These observations indicate that the presence of the HHV-8 genome in BM is relatively common in different groups of patients as well as in healthy individuals and do not support an alleged role for HHV-8 in MM.
引用
收藏
页码：188 / 190
页数：3
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