Targeted Therapies in Autoimmune Skin Diseases

被引：7
|
作者：
Braegelmann, Christine [1 ]
Niebel, Dennis [1 ]
Wenzel, Joerg [1 ]
机构：
[1] Univ Hosp Bonn, Dept Dermatol & Allergy, Venusberg Campus 1, D-53127 Bonn, Germany
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 3 PT B期
关键词：
IMMUNE-RESPONSE; MAST-CELLS; EXPRESSION; PATHWAY;
D O I：
10.1016/j.jid.2021.08.439
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Unlike the established anti-inflammatory drugs with a broad range, new-targeted therapeutic approaches have emerged in the management of autoimmune skin diseases to increase efficacy and decrease adverse reactions on the basis of an improved molecular understanding of pathogenesis. Most inflammatory dermatoses are driven by misled immune responses physiologically directed at exogenous pathogens, that is, type 1 immunity against viral pathogens, type 2 immunity against parasites, and type 3 immunity against fungi and bacteria. Pathogenic hallmarks of these major immune reaction patterns are characterized within this article, and a comprehensive overview of current clinical trials evaluating targeted therapeutics for respective dermatoses is outlined.
引用
收藏
页码：969 / +
页数：14
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