Enantioselective decarboxylative protonation and deuteration of β-ketocarboxylic acids

被引：10

作者：

Mizutani, Haruna ^{[1
]}

Kawanishi, Ryouta ^{[1
]}

Shibatomi, Kazutaka ^{[1
]}

机构：

[1] Toyohashi Univ Technol, Dept Appl Chem & Life Sci, 1-1 Hibarigaaka,Tempaku Cho, Toyohashi, Aichi 4418580, Japan

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 54期

关键词：

DERIVATIVES; ENANTIOMERS;

D O I：

10.1039/d1cc01610e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective decarboxylative protonation of tetralone-derived beta-ketocarboxylic acids was achieved with up to 89% enantiomeric excess (ee)-in the presence of a chiral primary amine catalyst. Furthermore, this method was applied to enantioselective deuteration to afford the corresponding alpha-deuterioketones with up to 88% ee.

引用

页码：6676 / 6679

页数：4

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