One-step synthesis of silica gel used in the controlled release of drug

被引：0

作者：

Signoretto, M. ^{[1
]}

Nichele, V. ^{[1
]}

Ghedini, Elena ^{[1
]}

Pinna, F. ^{[1
]}

Cerrato, G. ^{[2
]}

机构：

[1] Univ Venice, Dept Chem, Univ Ca Foscari Venice, Consortium INSTM,Res Unit, Calle Larga St Marta 2137, I-30123 Venice, Italy

[2] Univ Turin, Dept Chem IFM, I-10125 Turin, Italy

来源：

ZEOLITES AND RELATED MATERIALS: TRENDS, TARGETS AND CHALLENGES, PROCEEDINGS OF THE 4TH INTERNATIONAL FEZA CONFERENCE | 2008年 / 174卷

关键词：

Silica gel; ultrasound; modification; drug release;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Pure and modified silica materials were prepared by the sol-gel process and used as carrier for the controlled release of ibuprofen. A one-step synthesis was carried out for the preparation of the silica-drug composites and the sol-gel method was improved by using the ultrasounds in order to replace of acid or basic catalysts. It was found that the presence of methyl groups on the silica surface influences the drug delivery rate leading to a high degree of control of the desorption process.

引用

页码：489 / 492

页数：4

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