Urinary endotoxin excretion and urinary tract infection following kidney transplantation

被引:12
|
作者
Boelke, E [1 ]
Jehle, PM [1 ]
Storck, M [1 ]
Orth, K [1 ]
Schams, S [1 ]
Abendroth, D [1 ]
机构
[1] Univ Ulm, Dept Vasc & Thorac Surg, D-89075 Ulm, Germany
关键词
kidney transplantation; endotoxin; Limulus amebocyte lysate test; urinary tract infection;
D O I
10.1007/s001470100317
中图分类号
R61 [外科手术学];
学科分类号
摘要
Following kidney transplantation, urine endotoxin levels were measured among 44 patients and compared to bacterial cultures. Urine samples were collected either via transurethral catheters or - after removal of the catheter on postoperative day 4 - by midstream void. In a control group of ten healthy volunteers, urine endotoxin levels were measured daily for 10 days. Urinary endotoxin concentration was measured by means of a chromogenically modified Limulus amebocyte lysate (LAL) test. The levels among patients with positive bacteriological findings (n = 21) were always elevated (> 0.7 EU/ml). Furthermore, there was a marked, statistically significant difference in endotoxin values between samples with bacterial growth and samples with fungal or without any growth (P < 0.001). All 21 of the 44 patients with urinary tract infection (UTI) were endotoxin-positive. Seven more patients who received antibiotics had elevated urinary endotoxin levels, but no bacterial growth in the urine culture. No bacterial infection or significant urinary endotoxin was found in the control group. In summary, the detection of urinary endotoxin in samples obtained by either suprapubic/transurethral catheters or midstream void is an early, sensitive, and specific means of diagnosis that can be carried out even during antibiotic treatment.
引用
收藏
页码:307 / 310
页数:4
相关论文
共 50 条
  • [21] URINARY TRACT INFECTION AFTER KIDNEY TRANSPLANTATION: A RETROSPECTIVE OBSERVATIONAL STUDY
    Martins, Ana Rita
    Silva, Rui
    Matias, Patricia
    Jorge, Cristina
    Toscano, Cristina
    Adragao, Teresa
    Birne, Rita
    Weigert, Andre
    Bruges, Margarida
    Marques, Teresa
    Machado, Domingos
    TRANSPLANT INTERNATIONAL, 2013, 26 : 166 - 166
  • [23] URINARY-TRACT FUNGAL INFECTION FOLLOWING RENAL-TRANSPLANTATION
    MIR, M
    LLOVERAS, J
    DELASCUEVAS, X
    MASRAMON, J
    AUBIA, J
    ORFILA, A
    CHINE, M
    GIRBAU, J
    LLORACH, M
    SALVADO, M
    TORRELLA, T
    REVISTA CLINICA ESPANOLA, 1985, 176 (03): : 130 - 133
  • [24] Updates on urinary tract infections in kidney transplantation
    Fiorentino, Marco
    Pesce, Francesco
    Schena, Antonio
    Simone, Simona
    Castellano, Giuseppe
    Gesualdo, Loreto
    JOURNAL OF NEPHROLOGY, 2019, 32 (05) : 751 - 761
  • [25] Updates on urinary tract infections in kidney transplantation
    Marco Fiorentino
    Francesco Pesce
    Antonio Schena
    Simona Simone
    Giuseppe Castellano
    Loreto Gesualdo
    Journal of Nephrology, 2019, 32 : 751 - 761
  • [26] Fecal microbiota transplantation in a kidney transplant recipient with recurrent urinary tract infection
    Biehl, Lena M.
    Aguilar, Rebeca Cruz
    Farowski, Fedja
    Hahn, Werner
    Nowag, Angela
    Wisplinghoff, Hilmar
    Vehreschild, Maria J. G. T.
    INFECTION, 2018, 46 (06) : 871 - 874
  • [27] RISK FACTORS FOR URINARY TRACT INFECTION AFTER KIDNEY TRANSPLANTATION: A RETROSPECTIVE ANALYSIS
    Tekkarismaz, Nihan
    Ozelsancak, Ruya
    Micozkadioglu, Hasan
    Caliskan, Kenan
    Demiroglu, Yusuf Ziya
    Haberal, Mehmet
    TRANSPLANT INTERNATIONAL, 2019, 32 : 296 - 296
  • [28] Effects of Urinary Tract Infection in Patients With Bladder Augmentation and Kidney Transplantation COMMENT
    Koyle, Martin A.
    JOURNAL OF UROLOGY, 2008, 180 (06): : 2610 - 2610
  • [29] Analysis of risk factors for early urinary tract infection after kidney transplantation
    Ma, Zheng-Zheng
    Li, Li
    Han, Yan-Xia
    Duan, Ya-Dong
    Wang, Wei-Zhen
    Niu, Mei-E
    TRANSLATIONAL ANDROLOGY AND UROLOGY, 2020, 9 (05) : 2211 - 2217
  • [30] Native ureteropyelostomy: an effective therapy for urinary tract complications following kidney transplantation
    Riediger, Carina
    Mueller, Michael W.
    Bachmann, Jeannine
    Novotny, Alexander
    Thorban, Stefan
    Matevossian, Edouard
    Friess, Helmut
    Stangl, Manfred
    ANZ JOURNAL OF SURGERY, 2014, 84 (09) : 643 - 648