Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

被引：4
|
作者：
Chen, Muwan [1 ,2 ]
Maimaitili, Muyesier [1 ,2 ]
Buchholdt, Susanne Hvolbol [1 ,2 ]
Jensen, Uffe Birk [2 ,3 ]
Febbraro, Fabia [1 ,4 ]
Denham, Mark [1 ,2 ]
机构：
[1] Aarhus Univ, Danish Res Inst Translat Neurosci DANDRITE, Nordic EMBL Partnership Mol Med, Aarhus, Denmark
[2] Aarhus Univ, Dept Biomed, Aarhus, Denmark
[3] Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark
[4] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark
来源：
STEM CELL RESEARCH | 2020年 / 42卷
关键词：
D O I：
10.1016/j.scr.2019.101657
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.
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页数：5
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