[1] McGill Univ, Ctr Hlth, Montreal, PQ, Canada
[2] McGill Univ, Montreal, PQ, Canada
[3] Univ British Columbia, Xenon Genet Inc, Vancouver, BC V5Z 1M9, Canada
[4] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
[5] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada