Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

被引：149

作者：

Roe, M ^{[1
]}

Folkes, A ^{[1
]}

Ashworth, P ^{[1
]}

Brumwell, J ^{[1
]}

Chima, L ^{[1
]}

Hunjan, S ^{[1
]}

Pretswell, I ^{[1
]}

Dangerfield, W ^{[1
]}

Ryder, H ^{[1
]}

Charlton, P ^{[1
]}

机构：

[1] Xenova Ltd, Slough SL1 4EF, Berks, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00030-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：595 / 600

页数：6

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