Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin

被引：16
|
作者：
Song, Jihyeon [1 ]
Kim, Jun Yeong [1 ]
You, Gayeon [1 ]
Kang, Yoon Young [1 ]
Yang, Jiwon [1 ]
Mok, Hyejung [1 ]
机构：
[1] Konkuk Univ, Dept Biosci & Biotechnol, Seoul 05029, South Korea
来源：
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | 2022年 / 27卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
glycyrrhizic acid; curcumin; nanocomplexes; anti-cancer; anti-inflammatory; INDUCED INFLAMMATORY RESPONSE; INDUCED ARTHRITIS; NANOPARTICLES; LICORICE; DELIVERY; DRUG;
D O I：
10.1007/s12257-021-0198-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In this study, nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant (Glycyrrhiza glabra) were formulated for the delivery of curcumin (CUR). Sonication of amphiphilic GA solution with hydrophobic CUR resulted in the production of nanosized complexes with a size of 164.8 +/- 51.7 nm, which greatly enhanced the solubility of CUR in aqueous solution. A majority of the CURs were released from these GA/ CUR nanocomplexes within 12 h. GA/CUR nanocomplexes exhibited excellent intracellular uptake in human breast cancer cells (Michigan cancer foundation-7/multi-drug resistant cells), indicating enhanced anti-cancer effects compared to that of free CUR. In addition, GA/CUR nanocomplexes demonstrated high intracellular uptake into macrophages (RAW264.7 cells), consequently reducing the release of the pro-inflammatory cytokine tumor necrosis factor-alpha. Furthermore, GA/CUR nanocomplexes successfully reduced the levels of serum pro-inflammatory cytokines and splenomegaly in a rheumatoid arthritis model.
引用
收藏
页码：163 / 170
页数：8
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