Intellective and stimuli-responsive drug delivery systems in eyes

被引：35

作者：

Lin, Xueqi ^{[1
]}

Wu, Xingdi ^{[1
]}

Chen, Xiang ^{[1
]}

Wang, Ben ^{[2
,3
]}

Xu, Wen ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Eye Ctr, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, China Natl Minist Educ, Sch Med,Canc Inst,Key Lab Canc Prevent & Interven, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2021年 / 602卷

关键词：

Ocular drug delivery; Stimuli-responsive systems; Controlled release; Nanoparticle as delivery vehicle; IN-SITU GEL; FORMING INJECTABLE IMPLANTS; EMBEDDED CONTACT-LENSES; POSTERIOR SEGMENT; CONTROLLED-RELEASE; CANCER-TREATMENT; GELLING SYSTEMS; CHOROIDAL NEOVASCULARIZATION; CONDUCTING POLYMERS; HYDROGEN-PEROXIDE;

D O I：

10.1016/j.ijpharm.2021.120591

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Stimuli-responsive drug delivery systems have attracted widespread attention in recent years since they can control drug release in a spatiotemporal manner and can achieve tunable drug release according to patient's physiological or pathological condition. In this review, we briefly introduce the drug delivery barriers and drug delivery systems in the anterior and posterior segment of eyes, and collect the recent advances in stimuliresponsive drug delivery systems in eyes for controlled drug release in response to exogenous stimuli (ultrasound, magnetic stimulus, electrical stimulus, and light) or endogenous stimuli (enzyme, active oxygen species, temperature, ions, and pH). In addition, the design and mechanisms of the stimuli-responsive drug delivery systems have been summarized in this review, and the advantages and limitations are also briefly discussed.

引用

页数：17

共 50 条

[11] Stimuli-responsive drug delivery systems for inflammatory skin conditions
Gade, Luna
Boyd, Ben J.
Malmsten, Martin
Heinz, Andrea
ACTA BIOMATERIALIA, 2024, 187 : 1 - 19
[12] Stimuli-Responsive Prodrug Chemistries for Drug Delivery
Taresco, Vincenzo
Alexander, Cameron
Singh, Nishant
Pearce, Amanda K.
ADVANCED THERAPEUTICS, 2018, 1 (04)
[13] Stimuli-responsive polymers and their applications in drug delivery
Bawa, Priya
Pillay, Viness
Choonara, Yahya E.
du Toit, Lisa C.
BIOMEDICAL MATERIALS, 2009, 4 (02)
[14] DNA nanostructures for stimuli-responsive drug delivery
Wang T.
Liu Y.
Wu Q.
Lou B.
Liu Z.
Smart Materials in Medicine, 2022, 3 : 66 - 84
[15] Stimuli-responsive polypeptides for controlled drug delivery
Zhang, Peng
Li, Mingqian
Xiao, Chunsheng
Chen, Xuesi
CHEMICAL COMMUNICATIONS, 2021, 57 (75) : 9489 - 9503
[16] Stimuli-responsive hydrogels for intratumoral drug delivery
Marques, Ana C.
Costa, Paulo J.
Velho, Sergia
Amaral, Maria H.
DRUG DISCOVERY TODAY, 2021, 26 (10) : 2397 - 2405
[17] Stimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, Fenghua
Zhong, Zhiyuan
Feijen, Jan
BIOMACROMOLECULES, 2009, 10 (02) : 197 - 209
[18] Endogenous Stimuli-responsive Nanocarriers for Drug Delivery
Chen, Huachao
Liu, Danyang
Guo, Zijian
CHEMISTRY LETTERS, 2016, 45 (03) : 242 - 249
[19] Stimuli-Responsive and Multifunctional Nanogels in Drug Delivery
Ashwani, P. V.
Gopika, G.
Krishna, K. V. Arun
Jose, Josena
John, Franklin
George, Jinu
CHEMISTRY & BIODIVERSITY, 2023, 20 (11)
[20] Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer
Lin, Xu
Wu, Jiahe
Liu, Yupeng
Lin, Nengming
Hu, Jian
Zhang, Bo
MOLECULES, 2022, 27 (03):

← 1 2 3 4 5 →