Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity

被引：28
|
作者：
Yang, Jing [1 ]
Li, Yong-Chao [1 ]
Zhou, Xiu-Ren [1 ]
Xu, Xin-Juan [1 ]
Fu, Qing-Yun [1 ]
Liu, Chang-Zhong [2 ]
机构：
[1] Henan Inst Sci & Technol, Sch Life Sci & Technol, Hualan Rd, Xinxiang, Peoples R China
[2] Henan Inst Sci & Technol, Sch Anim Sci, Hualan Rd, Xinxiang, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 18期
关键词：
Lonicera japonica; thymol derivative; antibacterial effect; monoterpenoid; COUPLED SECOIRIDOIDS; GLYCOSIDES; BACTERIA; EXTRACTS; THUNB;
D O I：
10.1080/14786419.2017.1371153
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new monoterpenoid, 7-acetyl-8,9-dihydroxy thymol (1), together with a known one 7,8-dihydroxy-9-buyryl thymol (2), were isolated from the dried flower buds of Lonicera japonica Thunb. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses. The potential antibacterial effects of these compounds on Staphylococcus aureus, Escherichia coli, Micrococcus luteus, and Bacillus cereus were evaluated. Interestingly, both compounds 1 and 2 exhibited significant antibacterial activities with IC50 values range from 27.64 +/- 2.26 to 128.58 +/- 13.26 g/mL. [GRAPHICS] .
引用
收藏
页码：2238 / 2243
页数：6
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