Identification of potential HIV-1 targets of minocycline

被引：15
|
作者：
Jenwitheesuk, Ekachai
Samudrala, Ram [1 ]
机构：
[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA
[2] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Pathum Thani 12120, Thailand
来源：
BIOINFORMATICS | 2007年 / 23卷 / 20期
关键词：
D O I：
10.1093/bioinformatics/btm424
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Minocycline, a broad spectrum antibiotic, has been discovered to have inhibitory activity against HIV-1 in vitro, but the targets inhibited are unknown. We used a docking with dynamics protocol developed by us to predict the binding affinities of minocycline against seven active sites of five HIV-1 proteins to putatively identify the potential target(s) of minocycline. The results indicate that minocycline has the highest predicted binding affinity against HIV-1 integrase.
引用
收藏
页码：2797 / 2799
页数：3
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