Identification of potential HIV-1 targets of minocycline

被引：15

作者：

Jenwitheesuk, Ekachai

Samudrala, Ram ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[2] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Pathum Thani 12120, Thailand

来源：

BIOINFORMATICS | 2007年 / 23卷 / 20期

关键词：

D O I：

10.1093/bioinformatics/btm424

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Minocycline, a broad spectrum antibiotic, has been discovered to have inhibitory activity against HIV-1 in vitro, but the targets inhibited are unknown. We used a docking with dynamics protocol developed by us to predict the binding affinities of minocycline against seven active sites of five HIV-1 proteins to putatively identify the potential target(s) of minocycline. The results indicate that minocycline has the highest predicted binding affinity against HIV-1 integrase.

引用

页码：2797 / 2799

页数：3

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