Peroxide mediates ethanol-induced cytotoxicity in PC12 cells

被引：20
|
作者：
Li, YX [1 ]
Walker, DW [1 ]
King, MA [1 ]
机构：
[1] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 30卷 / 04期
关键词：
ethanol; hydrogen peroxide; PC12; cell; oxidative stress; free radicals;
D O I：
10.1016/S0891-5849(00)00484-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pheochromocytoma (PC12) cell cultures exhibited a loss of cells and increase in intracellular oxidative stress when exposed to ethanol (EtOH) for 24 h. Catalase, an enzyme that hydrolyzes hydrogen peroxide (H2O2) to O-2 and H2O can attenuate EtOH-induced cell loss and oxidative stress in PC12 cells. This study provides the first clear evidence that oxidative stress in the form of elevated intracellular H2O2 is a primary mechanism of EtOH neurotoxicity in PC12 cells. (C) 2001 Elsevier Science Inc.
引用
收藏
页码：389 / 392
页数：4
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