Soluble and insoluble polymeric 1,3-dithiane reagents for the synthesis of aldehydes from alkyl halides

被引：7

作者：

Bertini, V ^{[1
]}

Lucchesini, F ^{[1
]}

Pocci, M ^{[1
]}

Alfei, S ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Chim & Tecnol Farmaceut & Alimentari, I-16147 Genoa, Italy

来源：

TETRAHEDRON | 2005年 / 61卷 / 40期

关键词：

supported reagents; umpolung reactions; 1,3-dithianes aldehydes; alkyl halides;

D O I：

10.1016/j.tet.2005.07.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Through the synthesis and study of model systems as proper dithiane derivatives, vinyl monomers and soluble copolymeric reagents containing 2-unsubstituted 1,3-dithiane rings, we attained the key synthon 1,3-dithiane-5-methanol. Through its reaction with commercial resins, new polymeric reagents useful for supported organic synthesis and combinatorial chemistry were developed. Exploiting the reactivity of position 2 in 1,3-dithiane rings, such polymeric reagents were employed in the production of aldehydes from alkyl halides through a process entirely free from unpleasant odors. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：9519 / 9526

页数：8

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