Vitiligo - The story from within: A transmission electron microscopic study before and after narrow-band ultraviolet B

被引：5
|
作者：
Fawzy, Marwa M. [1 ]
El Maadawi, Zeinab M. [2 ]
Hegazy, Rehab A. [1 ]
Abd El Fatah, Nesrin S. [1 ]
机构：
[1] Cairo Univ, Dept Dermatol, Fac Med, Cairo, Egypt
[2] Cairo Univ, Dept Histol & Cell Biol, Fac Med, Cairo 11562, Egypt
来源：
ULTRASTRUCTURAL PATHOLOGY | 2016年 / 40卷 / 05期
关键词：
Narrow-band ultraviolet B; transmission electron microscopy; vitiligo; LESIONAL SKIN; MELANOCYTES; KERATINOCYTES; PROLIFERATION; MIGRATION; THERAPY; MODEL;
D O I：
10.1080/01913123.2016.1218987
中图分类号：
TH742 [显微镜];
学科分类号：
摘要：
Melanocyte loss is the main feature of vitiligo, but evidence refers to pathological multiplayers. Transmission electron microscopy was utilized to further explore vitiligo before and after narrow-band ultraviolet B (NB-UVB) therapy. Skin biopsies were retrieved from lesional and perilesional skin and compared to normal control skin. Sections were examined for melanocytes and keratinocytes and the number of melanosomes and thickness of basal lamina were measured. In lesional skin, keratinocytes revealed two types of degeneration with a significant increase in the mean thickness of basal lamina and decrease in the number of melanosomes. After treatment, lesional and perilesional skin showed variable ultrastructural features.
引用
收藏
页码：265 / 275
页数：11
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