Diastereo- and Enantioselective 1,4-Difunctionalization of Borylenynes by Catalytic Conjunctive Cross-Coupling

被引：40

作者：

Law, Chunyin ^{[1
]}

Kativhu, Elton ^{[1
]}

Wang, Johnny ^{[1
]}

Morken, James P. ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, 2609 Beacon St, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 26期

基金：

美国国家卫生研究院;

关键词：

boronates; chirality; cross-coupling; homogeneous catalysis; palladium; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; INTERMOLECULAR ADDITION; ALPHA-HYDROXYALLENES; CYCLIZATION REACTION; CHIRALITY TRANSFER; ALLENES; ISOMERIZATION; EPOXIDES; HYDROSILYLATION;

D O I：

10.1002/anie.202001580

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective conjunctive cross-coupling of enyne-derived boronate complexes occurs with 1,4 addition of the electrophile and migrating group across the pi system. This reaction pathway furnishes alpha-boryl allenes as the reaction product. In the presence of a chiral catalyst, both the central and axial chirality of the product can be controlled during product formation.

引用

页码：10311 / 10315

页数：5

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