Preventing and Reversing Opiate-Induced Persistent Postoperative Cognitive Dysfunction in Aged Male Rats With Selective TLR4 Antagonist

被引:0
|
作者
Barrientos, Ruth [1 ]
Muscat, Stephanie [1 ]
Deems, Nicholas [1 ]
Maier, Steven [1 ]
机构
[1] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA
关键词
Postoperative Cognitive Dysfunction; Alzheimer's Disease; Toll-Like Receptors (TLRs); Opioids; Opioid Antagonist Treatment;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
P16
引用
收藏
页码:80 / 80
页数:1
相关论文
共 50 条
  • [31] VIP alleviates sepsis-induced cognitive dysfunction as the TLR-4/NF-κB signaling pathway is inhibited in the hippocampus of rats
    Yujiao Yang
    Debo Yun
    Biqian Dong
    Yuan Geng
    Yong Wan
    Journal of Molecular Histology, 2022, 53 : 369 - 377
  • [32] Hippocampal Galectin-3 knockdown alleviates lipopolysaccharide-induced neurotoxicity and cognitive deficits by inhibiting TLR4/NF-?B signaling in aged mice
    Chen, Fang
    Wu, Xiaofeng
    Yang, Jiayong
    Yu, Xuben
    Liu, Bili
    Yan, Zhiwen
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2022, 936
  • [33] Magnesium sulfate ameliorates sepsis-induced diaphragm dysfunction in rats via inhibiting HMGB1/TLR4/NF-κB pathway
    Jiang, Jihong
    Chen, Qi
    Chen, Xia
    Li, Jinbao
    Li, Shitong
    Yang, Bin
    NEUROREPORT, 2020, 31 (12) : 902 - 908
  • [34] Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy
    Arab, Hany H.
    Elhemiely, Alzahraa A.
    El-Sheikh, Azza A. K.
    Al Khabbaz, Hana J.
    Arafa, El-Shaimaa A.
    Ashour, Ahmed M.
    Kabel, Ahmed M.
    Eid, Ahmed H.
    PHARMACEUTICALS, 2022, 15 (07)
  • [35] Cognitive dysfunction induced by cranial irradiation: effect of Ginkgo biloba extract (EGb 761) in 4-month-old male rats
    Lamproglou, I
    Boisserie, G
    Vranckx, R
    Baillet, F
    Bok, B
    Drieu, K
    ADAPTIVE EFFECTS OF GINKGO BILOBA EXTRACT (EGB 761), 1997, 6 : 73 - 87
  • [36] Betulinic acid reduces inflammation in rats with sepsis-induced myocardial dysfunction by inhibiting TLR4/MyD88/NF-κB signaling pathway
    Wang, Lei
    Fei, Wei-yu
    Song, Qian-ying
    CHEMICAL BIOLOGY & DRUG DESIGN, 2024, 103 (02)
  • [37] Short-term consumption of a high-fat diet makes post-operative cognitive dysfunction persistent & induces anxiety-like behaviors in aged male rats
    Muscat, Stephanie
    Deems, Nicholas
    Butler, Michael
    Barrientos, Ruth
    BRAIN BEHAVIOR AND IMMUNITY, 2022, 106 : 38 - 38
  • [38] Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats
    Yang, Jiali
    Jia, Zhixia
    Xiao, Zhigang
    Zhao, Jing
    Lu, Ye
    Chu, Li
    Shao, Hui
    Pei, Lin
    Zhang, Shaodan
    Chen, Yuan
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 15 : 3163 - 3180
  • [39] Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats
    Muhammed A. Saad
    Muhammad Y. Al-Shorbagy
    Hany H. Arab
    Molecular Neurobiology, 2022, 59 : 4562 - 4577
  • [40] S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway (vol 44, pg 221, 2015)
    Lu, Shun-Mei
    Yu, Chan-Juan
    Liu, Ya-Hua
    Dong, Hong-Quan
    Zhang, Xiang
    Zhang, Su-Su
    Hu, Liu-Qing
    Zhang, Feng
    Qian, Yan-Ning
    Gui, Bo
    BRAIN BEHAVIOR AND IMMUNITY, 2020, 89 : 694 - 695