Effect of trans-retinoic acid and folic acid on apoptosis in human gastric cancer cell lines MKN-45 and MKN-28

被引：13

作者：

Fang, JY ^{[1
]}

Xiao, SD ^{[1
]}

机构：

[1] Shanghai Med Univ 2, Shanghai Inst Digest Dis, Shanghai 200001, Peoples R China

来源：

JOURNAL OF GASTROENTEROLOGY | 1998年 / 33卷 / 05期

关键词：

gastric cancer cell lines; apoptosis; retinoic acid; folic acid;

D O I：

10.1007/s005350050152

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Induction of apoptosis has been implicated as an anticarcinogentic mechanism of both folic acid and retinoic acid. The ability of retinoic acid or folic acid to induce gastric cancer cell apoptosis was investigated in the human gastric cancer cell lines MKN-45 and MKN-28, and DNA fragmentation was studied in situ by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling and DNA agarose gel electrophoresis. The rates of apoptosis in both the poorly differentiated MKN-45 and the well differentiated MKN-28 cell line were less than 5% after treatment with either retinoic or folic acid. Apoptosis may be induced by the administration of retinoic acid or folic acid, and the apoptosis indices of MKN-45 and MKN-28 cells were related to the doses of these drugs. The induction of gastric cancer cell apoptosis may play a role in the anticarcinogenetic effect of retinoic acid and folic acid, both of which are potential agents for the treatment of human gastric cancer.

引用

页码：656 / 661

页数：6

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