Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

被引：46

作者：

Wang, Lisheng ^{[1
]}

You, Yejun ^{[1
]}

Wang, Songqing ^{[1
]}

Liu, Xu ^{[1
]}

Liu, Buming ^{[2
]}

Wang, Jinni ^{[3
]}

Lin, Xiao ^{[2
]}

Chen, Mingsheng ^{[2
]}

Liang, Gang ^{[3
]}

Yang, Hua ^{[1
]}

机构：

[1] Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Peoples R China

[2] Guangxi Inst Tradit Med & Pharmaceut Sci, Guangxi Key Lab Tradit Chinese Med Qual Stand, Nanning 530022, Peoples R China

[3] Guangxi Med Univ, Coll Pharm, Nanning 530022, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 12期

关键词：

Matrine derivative; Synthesis; Anti-tumor activity; ASYMMETRIC-SYNTHESIS; ACID;

D O I：

10.1016/j.bmcl.2012.04.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4100 / 4102

页数：3

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