Do follicle-stimulating hormone receptor polymorphisms in infertile men influence intracytoplasmic sperm injection outcomes? A prospective cohort study
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Fakih, Chadi
[1
,2
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Raad, Georges
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Al Hadi Lab & Med Ctr, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Raad, Georges
[1
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Ghamloush, Mona
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Al Hadi Lab & Med Ctr, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Ghamloush, Mona
[1
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Bazzi, Marwa
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Al Hadi Lab & Med Ctr, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Bazzi, Marwa
[1
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Fakih, Ibrahim
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St Joseph Univ USJ, Fac Sci, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Fakih, Ibrahim
[3
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Safi, Neemtallah
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Lebanese Univ, Fac Med, Dept Obstet & Gynecol, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Safi, Neemtallah
[2
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Costantine, Claira
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Lebanese Univ, Fac Med, Dept Obstet & Gynecol, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Costantine, Claira
[2
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Mourad, Youmna
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Al Hadi Lab & Med Ctr, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
Mourad, Youmna
[1
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Fakih, Fadi
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Al Hadi Lab & Med Ctr, Beirut, LebanonAl Hadi Lab & Med Ctr, Beirut, Lebanon
The follicle-stimulating hormone (FSH) and its receptor regulate the quantity and quality of spermatozoa production. Several studies have analyzed the effect of single nucleotide polymorphisms (SNPs) in exon 10 of the FSH receptor (FSHR) on basic semen parameters without yet reaching a firm consensus. The aim of this study was to evaluate the effect of p.Thr307Ala and p.Asn680Ser polymorphisms in exon 10 of the FSHR gene, in infertile men, on intracytoplasmic sperm injection (ICSI) outcomes. This study was conducted between March 2019 and February 2020 on infertile couples undergoing ICSI at Al Hadi Laboratory and Medical Center, Lebanon. Couples with severe infertility factors that may impair gametogenesis/embryogenesis (e.g. advanced maternal age, premature ovarian failure, underwent gonadotoxic treatments, etc.) were excluded from the study. Semen and blood samples were collected from infertile men on the day of oocyte collection. Infertile men (n = 173) were screened for FSHR variants using polymerase chain reaction-restriction fragment length polymorphism. Moreover, fertilization rates, embryo quality, and pregnancy outcomes were evaluated. Higher sperm concentrations were found in the p.Thr307Ala group than the p.Thr307Thr (P < 0.01) and p.Ala307Ala (P < 0.05) groups. Furthermore, fertilization rate was significantly lower in the p.Ala307Ala genotype than in the p.Thr307Thr genotype (P < 0.05). We showed that FSHR variants in infertile men undergoing ICSI could affect sperm concentration, motility, and fertilization rates. Therefore, it will be important to confirm these results in further studies using a larger sample size.
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Cent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Cent S Univ, Sch Pharmaceut Sci, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Yan, Yuanliang
Gong, Zhicheng
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Cent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Gong, Zhicheng
Zhang, Lu
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Cent S Univ, Xiangya Hosp, Ctr Mol Med, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Zhang, Lu
Li, Yanping
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Cent S Univ, Xiangya Hosp, Dept Reprod Med, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Li, Yanping
Li, Xiong
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Cent S Univ, Xiangya Hosp, Ctr Mol Med, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Li, Xiong
Zhu, Lin
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Cent S Univ, Xiangya Hosp, Dept Reprod Med, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
Zhu, Lin
Sun, Lunquan
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Cent S Univ, Xiangya Hosp, Ctr Mol Med, Changsha, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Papaleo, Enrico
De Santis, Lucia
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
De Santis, Lucia
Fusi, Francesco
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Fusi, Francesco
Doldi, Nicola
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Doldi, Nicola
Brigante, Claudio
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Brigante, Claudio
Marelli, Guido
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Marelli, Guido
Persico, Paola
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Persico, Paola
Cino, Ilaria
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy
Cino, Ilaria
Ferrari, Augusto
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Univ Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, ItalyUniv Vita Salute San Raffaele, IRCCS San Raffaele Hosp, Gynaecol Obstet Dept, IVF Unit, Milan, Italy