Tumor necrosis factor-α and its receptors in epithelial ovarian cancer

被引：19
|
作者：
Dobrzycka, Bozena [1 ]
Terlikowski, Slawomir J. [1 ]
Garbowicz, Magdalena [2 ]
Niklinska, Wieslawa [3 ]
Bernaczyk, Piotr S. [4 ]
Niklinski, Jacek [2 ]
Kinalski, Maciej [5 ]
Chyczewski, Lech [4 ]
机构：
[1] Med Univ Bialystok, Dept Obstet Gynecol & Obstet Gynecol Care, PL-15062 Bialystok, Poland
[2] Med Univ Bialystok, Dept Clin Mol Biol, PL-15062 Bialystok, Poland
[3] Med Univ Bialystok, Dept Histol & Embryol, PL-15062 Bialystok, Poland
[4] Med Univ Bialystok, Dept Pathomorphol, PL-15062 Bialystok, Poland
[5] Dist Hosp, Dept Gynecol, Bialystok, Poland
来源：
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2009年 / 47卷 / 04期
关键词：
tumor necrosis factor-alpha (TNF-alpha); tumor necrosis factor receptor 1 (TNF-R1); tumor necrosis factor receptor 2 (TNF-R2); epithelial ovarian cancer (EOC); TNF-ALPHA; BENIGN; SERUM; INFLAMMATION; HYPERPLASIA; PROGRESSION; EXPRESSION;
D O I：
10.2478/v10042-008-0117-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-alpha, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-alpha and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.
引用
收藏
页码：609 / 613
页数：5
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