Michael addition of 1,3-dicarbonyl compounds with etacrynic acid

被引：0
|
作者：
Gorlitzer, K
Diers, K
机构：
来源：
PHARMAZIE | 1996年 / 51卷 / 10期
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The product 2, formed by Michael addition of ethyl acetoacetate with etacrynic acid (1) yields the cyclohexenone 3 by acidic hydrolysis. Compared 3 is also obtained by heating 1 with acetylacetone and sodium ethanolate. Compound 3 reacts with pyridinium bromide perbromide (PBPB) to give the dibromophenol 4. The lactone 9 is received from the Michael-adduct of diethyl malonic acid with 1 followed by hydrolysis and reduction.
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页码：704 / 707
页数：4
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