Proteomics in antibiotic resistance and tolerance research: Mapping the resistome and the tolerome of bacterial pathogens

被引:5
|
作者
Sulaiman, Jordy Evan [1 ]
Lam, Henry [1 ]
机构
[1] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
关键词
Antibiotic; persistence; proteomics; resistance; tolerance; OXYGEN SPECIES PLAY; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; AMINOGLYCOSIDE ANTIBIOTICS; CIPROFLOXACIN RESISTANCE; QUINOLONE RESISTANCE; MULTIDRUG TOLERANCE; PERSISTER CELLS; MECHANISMS;
D O I
10.1002/pmic.202100409
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Antibiotic resistance, the ability of a microbial pathogen to evade the effects of antibiotics thereby allowing them to grow under elevated drug concentrations, is an alarming health problem worldwide and has attracted the attention of scientists for decades. On the other hand, the clinical importance of persistence and tolerance as alternative mechanisms for pathogens to survive prolonged lethal antibiotic doses has recently become increasingly appreciated. Persisters and high-tolerance populations are thought to cause the relapse of infectious diseases, and provide opportunities for the pathogens to evolve resistance during the course of antibiotic therapy. Although proteomics and other omics methodology have long been employed to study resistance, its applications in studying persistence and tolerance are still limited. However, due to the growing interest in the topic and recent progress in method developments to study them, there have been some proteomic studies that yield fresh insights into the phenomenon of persistence and tolerance. Combined with the studies on resistance, these collectively guide us to novel molecular targets for the potential drugs for the control of these dangerous pathogens. In this review, we surveyed previous proteomic studies to investigate resistance, persistence, and tolerance mechanisms, and discussed emerging experimental strategies for studying these phenotypes with a combination of adaptive laboratory evolution and high-throughput proteomics.
引用
收藏
页数:22
相关论文
共 50 条
  • [21] The prevalence of antibiotic resistance in bacterial respiratory pathogens from Norway is low
    Kristiansen, BE
    Sandnes, RA
    Mortensen, L
    Tveten, Y
    Vorland, L
    CLINICAL MICROBIOLOGY AND INFECTION, 2001, 7 (12) : 682 - 687
  • [22] Phenotypic tolerance: Antibiotic enrichment of noninherited resistance in bacterial populations
    Wiuff, C
    Zappala, RM
    Regoes, RR
    Garner, KN
    Baquero, F
    Levin, BR
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (04) : 1483 - 1494
  • [23] Environmental risks in swine biogas slurry-irrigated soils: A comprehensive analysis of antibiotic residues, resistome, and bacterial pathogens
    Zeng, Jie-Yi
    Meng, Miaoling
    Qi, Lin
    Li, Yaying
    Yao, Huaiying
    ENVIRONMENT INTERNATIONAL, 2024, 191
  • [24] Interplay of antibiotic resistance and food-associated stress tolerance in foodborne pathogens
    Liao, Xinyu
    Ma, Yanna
    Daliri, Eric Banan-Mwine
    Koseki, Shigenobu
    Wei, Shuai
    Liu, Donghong
    Ye, Xingqian
    Chen, Shiguo
    Ding, Tian
    TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2020, 95 : 97 - 106
  • [25] Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study
    Asbell, Penny A.
    DeCory, Heleen H.
    PLOS ONE, 2018, 13 (10):
  • [26] Research Progress on Bacterial Membrane Vesicles and Antibiotic Resistance
    Liu, Xiaofei
    Xiao, Jinyang
    Wang, Shuming
    Zhou, Jinxia
    Qin, Jiale
    Jia, Zhibo
    Wang, Yanfeng
    Wang, Zhigang
    Zhang, Yongmin
    Hao, Huifang
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
  • [27] Global trend of antimicrobial resistance in common bacterial pathogens in response to antibiotic consumption
    Hou, Jie
    Long, Xiang
    Wang, Xiaolong
    Li, Linyun
    Mao, Daqing
    Luo, Yi
    Ren, Hongqiang
    JOURNAL OF HAZARDOUS MATERIALS, 2023, 442
  • [28] Antibiotic Resistance in Selected Emerging Bacterial Foodborne Pathogens-An Issue of Concern?
    Grudlewska-Buda, Katarzyna
    Bauza-Kaszewska, Justyna
    Wiktorczyk-Kapischke, Natalia
    Budzynska, Anna
    Gospodarek-Komkowska, Eugenia
    Skowron, Krzysztof
    ANTIBIOTICS-BASEL, 2023, 12 (05):
  • [29] Assessment of the Role of Wastewater Treatment Plant in Spread of Antibiotic Resistance and Bacterial Pathogens
    Yogesh S. Nimonkar
    Bhoomika Yadav
    Payal Talreja
    Ashutosh Sharma
    Shalaka Patil
    Sunita S. Saware
    Dilip R. Ranade
    Om Prakash
    Indian Journal of Microbiology, 2019, 59 : 261 - 265
  • [30] Assessment of the Role of Wastewater Treatment Plant in Spread of Antibiotic Resistance and Bacterial Pathogens
    Nimonkar, Yogesh S.
    Yadav, Bhoomika
    Talreja, Payal
    Sharma, Ashutosh
    Patil, Shalaka
    Saware, Sunita S.
    Ranade, Dilip R.
    Prakash, Om
    INDIAN JOURNAL OF MICROBIOLOGY, 2019, 59 (03) : 261 - 265