Novel alternative splicing in the 5′ exon of the neurotrophin-3 gene

被引：4
|
作者：
Sekimoto, M
Fukamachi, K
Nemoto, F
Miyata, S
Degawa, M
Senba, E
Ueyama, T
Nemoto, K
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Lab Hlth Sci, Shizuoka 4228526, Japan
[2] Wakayama Med Coll, Dept Neurobiol & Anat, Wakayama, Japan
来源：
NEUROREPORT | 1998年 / 9卷 / 16期
关键词：
alternative splicing; expression; mRNA; nucleotide sequence; neurotrophin-3; neurotrophin factor;
D O I：
10.1097/00001756-199811160-00020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE neurotrophin-3 (NT-3) gene has previously been reported to consist of three exons including two 5' short untranslated exons and a 3' long exon encoding the entire protein, and to give rise to two classes of transcripts by alternative splicing of the 5' exons to the 3' coding exon. In the present study, we demonstrated the presence of at least four new classes of transcripts of the NT-3 gene, in addition to the two known transcripts. The present finding proposes the further complexity of the regulational mechanism for NT-3 expression. NeuroReport 9: 3675-3679 (C) 1998 Lippincott Williams & Wilkins.
引用
收藏
页码：3675 / 3679
页数：5
相关论文
共 50 条
  • [21] Neurotrophin-3 modulates synaptic transmission
    Hernandez-Echeagaray, Elizabeth
    HORMONES AND SYNAPSE, 2020, 114 : 71 - 89
  • [22] Role of neurotrophin-3 in oligodendrocyte development
    Kumar, S
    Rousselot, P
    de Vellis, J
    JOURNAL OF NEUROCHEMISTRY, 1999, 73 : S179 - S179
  • [23] Novel exon combinations generated by alternative splicing of gene fragments mobilized by a CACTA transposon in Glycine max
    Gracia Zabala
    Lila Vodkin
    BMC Plant Biology, 7
  • [24] Neurotrophin-3 improves functional constipation
    Parkman, HP
    Rao, SSC
    Reynolds, JC
    Schiller, LR
    Wald, A
    Miner, PB
    Lembo, AJ
    Gordon, JM
    Drossman, DA
    Waltzman, L
    Stambler, N
    Cedarbaum, JM
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (06): : 1338 - 1347
  • [25] Novel exon combinations generated by alternative splicing of gene fragments mobilized by a CACTA transposon in Glycine max
    Zabala, Gracia
    Vodkin, Lila
    BMC PLANT BIOLOGY, 2007, 7
  • [26] An alternative splicing product of the lamin A/C gene lacks exon 10
    Machiels, BM
    Zorenc, AHG
    Endert, JM
    Kuijpers, HJH
    vanEys, GJJM
    Ramaekers, FCS
    Broers, JLV
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (16) : 9249 - 9253
  • [27] Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression
    Zheng, ZM
    JOURNAL OF BIOMEDICAL SCIENCE, 2004, 11 (03) : 278 - 294
  • [28] Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3
    Wright, DE
    Zhou, L
    Kucera, J
    Snider, WD
    NEURON, 1997, 19 (03) : 503 - 517
  • [29] Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies
    Zhou, Jianhua
    Yu, Qingming
    Zou, Tie
    BMC NEUROSCIENCE, 2008, 9 (Suppl 2)
  • [30] Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons
    De Giorgio, R
    Arakawa, J
    Wetmore, CJ
    Sternini, C
    PEPTIDES, 2000, 21 (09) : 1421 - 1426
12345