New potent and selective PDE10A inhibitors for the treatment of schizophrenia

被引:0
|
作者
Malamas, Michael S.
Ni, Yike
Erdei, James
Fan, Kristi
Hoefgen, Norbert
Stange, Hans
Schindler, Rudolf
Grunwald, Christian
Egerland, Ute
Langen, Barbara
Hage, Thorsten
Kronbach, Thomas
Grauer, Steven
Harrison, Boyd
Robichaud, Albert
Marquis, Karen
Comery, Thomas
Dunlop, John
Pangalos, Menelas
Brandon, Nicholas
机构
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
3-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [41] N-Methylanilide and N-methylbenzamide derivatives as novel selective phosphodiesterase 10A (PDE10A) inhibitors
    Kilburn, Paul
    Kehler, Jan
    Langgaard, Morten
    Larsen, Mogens
    Christoffersen, Claus
    Nielsen, Jacob
    Erichsen, Mette
    Petersen, Sebastion
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [42] PDE10A inhibitor in addiction
    MU Ying
    ZHEN Xue-chu
    中国药理学与毒理学杂志, 2017, 31 (05) : 455 - 456
  • [43] Molecular mechanisms for the putative antipsychotic activity of PDE10A inhibitors: PDE10A regulation of intracellular signaling in striatal medium spiny neurons in culture
    Menniti, FS
    Brown, T
    Collins, M
    Fox, C
    Kimmel, L
    Kleiman, R
    Lebel, L
    Ryan, A
    Schmidt, CJ
    Seeger, T
    Shrikhande, A
    Wong, S
    Wylie, R
    SCHIZOPHRENIA RESEARCH, 2003, 60 (01) : 313 - 314
  • [44] Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
    Chen, Liu
    Chen, Danqi
    Tang, Le
    Ren, Jing
    Chen, Jiaojiao
    Zhen, Xuechu
    Liu, Yu-Chih
    Zhang, Chenhua
    Luo, Haibin
    Shen, Jingkang
    Xiong, Bing
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (13) : 3315 - 3329
  • [45] Emerging Biology of PDE10A
    Wilson, Lindsay S.
    Brandon, Nicholas J.
    CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (03) : 378 - 388
  • [46] PDE10A inhibitors: An assessment of the current CNS drug discovery landscape
    Chappie, Tom
    Humphrey, John
    Menniti, Frank
    Schmidt, Chris
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2009, 12 (04) : 458 - 467
  • [47] Synthesis of fluorine-containing papaverine analogs as PDE10A inhibitors
    Zhang, Zhanbin
    Xu, Jinbin
    Mach, Robert
    Tu, Zhude
    JOURNAL OF NUCLEAR MEDICINE, 2009, 50
  • [48] BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase 10A (PDE10A) inhibitors
    Vlasceanu, Alexandru
    Jessing, Mikkel
    Kilburn, John Paul
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (15) : 4453 - 4461
  • [49] Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
    Rzasa, Robert M.
    Hu, Essa
    Rumfelt, Shannon
    Chen, Ning
    Andrews, Kristin L.
    Chmait, Samer
    Falsey, James R.
    Zhong, Wenge
    Jones, Adrie D.
    Porter, Amy
    Louie, Steven W.
    Zhao, Xiaoning
    Treanor, James J. S.
    Allen, Jennifer R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (24) : 7371 - 7375
  • [50] Design of potent & selective PDE5 inhibitors for treatment of MED.
    Bunnage, ME
    Mathias, JP
    Street, SDA
    Wood, A
    Beaumont, KC
    Ballard, SA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U5 - U5