A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

被引：13
|
作者：
Popa, Olivia M. [2 ]
Bojinca, Mihai [3 ]
Bojinca, Violeta [4 ]
Dutescu, Monica I. [5 ]
Meirosu, Mihaela [6 ]
Caisan, Ruxandra E. [5 ]
Ciofu, Claudia [3 ]
Bara, Constantin [2 ]
Popa, Luis O. [1 ]
机构：
[1] Grigore Antipa Natl Museum Nat Hist, Dept Mol Biol, Bucharest 011341, Romania
[2] Univ Carol Davila, Fac Med, Dept Immunol & Pathophysiol, Bucharest 041914, Romania
[3] Univ Carol Davila, IC Cantacuzino Hosp, Fac Med, Dept Rheumatol, Bucharest 020475, Romania
[4] Univ Carol Davila, St Maria Hosp, Dept Rheumatol, Fac Med, Bucharest 011172, Romania
[5] Prof Dr CT Nicolau Natl Inst Blood Transfus, Bucharest 011155, Romania
[6] ICA Res & Dev, Bucharest 013721, Romania
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 08期
关键词：
tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis; MICA RATHER; TNF; CYTOKINE; THERAPY; SPONDYLOARTHROPATHIES; CLASSIFICATION; PATHOGENESIS; INFLIXIMAB; EXPRESSION; CRITERIA;
D O I：
10.3390/ijms12085052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The -857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05-2.57) and in combined haplotypes with the -238G/A and -308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.
引用
收藏
页码：5052 / 5059
页数：8
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