A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

被引：13

作者：

Popa, Olivia M. ^{[2
]}

Bojinca, Mihai ^{[3
]}

Bojinca, Violeta ^{[4
]}

Dutescu, Monica I. ^{[5
]}

Meirosu, Mihaela ^{[6
]}

Caisan, Ruxandra E. ^{[5
]}

Ciofu, Claudia ^{[3
]}

Bara, Constantin ^{[2
]}

Popa, Luis O. ^{[1
]}

机构：

[1] Grigore Antipa Natl Museum Nat Hist, Dept Mol Biol, Bucharest 011341, Romania

[2] Univ Carol Davila, Fac Med, Dept Immunol & Pathophysiol, Bucharest 041914, Romania

[3] Univ Carol Davila, IC Cantacuzino Hosp, Fac Med, Dept Rheumatol, Bucharest 020475, Romania

[4] Univ Carol Davila, St Maria Hosp, Dept Rheumatol, Fac Med, Bucharest 011172, Romania

[5] Prof Dr CT Nicolau Natl Inst Blood Transfus, Bucharest 011155, Romania

[6] ICA Res & Dev, Bucharest 013721, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 08期

关键词：

tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis; MICA RATHER; TNF; CYTOKINE; THERAPY; SPONDYLOARTHROPATHIES; CLASSIFICATION; PATHOGENESIS; INFLIXIMAB; EXPRESSION; CRITERIA;

D O I：

10.3390/ijms12085052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The -857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05-2.57) and in combined haplotypes with the -238G/A and -308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.

引用

页码：5052 / 5059

页数：8

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