Asymmetrical changes in blood-brain barrier permeability during pentylenetetrazol-induced seizures and in acute hypertension

被引：10
|
作者：
Öztas, B [1 ]
机构：
[1] Univ Istanbul, Istanbul Fac Med, Dept Physiol, TR-34390 Capa Istanbul, Turkey
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 1998年 / 82卷 / 02期
关键词：
blood-brain barrier; cerebral asymmetry; seizure; pentylenetetrazol;
D O I：
10.1016/S0925-4927(98)00014-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The asymmetrical breakdown of the blood-brain barrier to Evans-blue was studied in male and female rats during epileptiform seizures and in acute hypertension. The animals were divided into six groups. Group I: control female; Group II: control male; Group III: female + acute hypertension; Group IV: male + acute hypertension; Group V: female + seizure; Group VI: male + seizure. Asymmetric breakdown of the blood-brain barrier had been seen in female rats treated with pentylenetetrazol. Pentylenetetrazol-induced seizure produces less disruption of the blood-brain barrier in right cerebral hemisphere than in left cerebral hemisphere in female rats. There were no asymmetrical changes of blood-brain barrier;permeability between the left and right hemispheres in acute hypertension in both sexes, and male rats treated with pentylenetetrazol. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：129 / 133
页数：5
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