Kidney transplantation for end-stage renal disease in lupus nephritis, a very safe procedure: a single Latin American transplant center experience

被引:21
|
作者
Naranjo-Escobar, J. [1 ,2 ]
Manzi, E. [3 ]
Posada, J. G. [4 ]
Mesa, L. [4 ]
Echeverri, G. J. [5 ]
Duran, C. [4 ]
Schweneiberg, J. [4 ]
Caicedo, L. A. [5 ]
Villegas, J. I. [5 ]
Tobon, G. J. [2 ,6 ,7 ]
机构
[1] Fdn Valle Lili, Rheumatol Unit, Cali, Colombia
[2] ICESI Univ, Sch Med, Cali, Colombia
[3] Fdn Valle Lili, Transplant Unit, Ctr Clin Res, Cali, Colombia
[4] Fdn Valle Lili, Internal Med & Nephrol Unit, Cali, Colombia
[5] Fdn Valle Lili, Abdominal Transplantat Surg, Cali, Colombia
[6] Fdn Valle Lili, Rheumatol Unit, Cali, Colombia
[7] Fdn Valle Lili, Lab Immunol, Cali, Colombia
关键词
Systemic lupus erythematosus; lupus nephritis; end-stage renal disease; kidney transplant; CLINICAL-OUTCOMES; RISK-FACTORS; ERYTHEMATOSUS; RECURRENCE; RECIPIENTS; SECONDARY;
D O I
10.1177/0961203317696591
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Lupus nephritis (LN) is one of the most frequent complications of SLE and occurs in up to 50% of cases depending on the studied population. Of these, approximately 20% progress to end-stage renal disease (ESRD), with the treatment of choice being a kidney transplant. Objective The objective of this study was to describe the clinical outcome of patients transplanted due to LN, compared with patients transplanted for other causes, in a Latin American population from the Fundacion Valle del Lili in Cali, Colombia. Methods Observational, retrospective case study with controls matched by age, sex and type of donor in a single center between 1996 and 2014. Results Sixty-five kidney transplants were performed in patients with LN and ESRD. The survival of patients with LN was 98% at 1, 10 and 15 years (p=.99). For controls by age and sex, survival was also 98% at 15 years post-transplant, and for controls by donor, the survival rate was 100% at 5 years and 98% at 15 years. Graft survival in patients with LN to 1, 5 and 15 years was 92%, 83% and 71%, respectively; for controls by age and sex, it was 90%, 84% and 64%, respectively, and for the controls by donor, it was 89%, 86% and 79%, respectively (p=.7718). There were no statistically significant differences found in the cumulative incidence of acute graft rejection in the first year, but it was found that acute rejection is a factor that relates to the loss of function of the renal graft (p=.032). Of the patients transplanted for LN, two (3.1%) experienced a recurrence of the disease. One patient died after a diagnosis of recurrence of LN due to an infection. Conclusions Kidney transplantation is a good option for patients with ESRD due to LN. In this Hispanic population, the survival of patients, graft survival, and cumulative incidence of graft rejection are not different from those of other transplanted patients. In addition, recurrence of LN was rare, showing the benefits of renal transplantation in LN patients with ESRD.
引用
收藏
页码:1157 / 1165
页数:9
相关论文
共 50 条
  • [41] Pancreas Transplant Recipients with End-Stage Renal Disease Benefit from Kidney Transplantation.
    Tang, Y.
    Zhu, Z.
    Huang, S.
    Zhang, Z.
    Ju, W.
    Guo, Z.
    He, X.
    Chen, G.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 : 431 - 432
  • [42] Liver transplant recipients with end-stage renal disease largely benefit from kidney transplantation
    Ju, W.
    Tang, Y.
    Guo, Z.
    He, X.
    TRANSPLANTATION, 2018, 102 : 122 - 122
  • [43] Liver Transplant Recipients With End-Stage Renal Disease Largely Benefit From Kidney Transplantation
    Yunhua, T.
    Qiang, Z.
    Lipeng, J.
    Shanzhou, H.
    Zebin, Z.
    Fei, J.
    Zhiheng, Z.
    Linhe, W.
    Weiqiang, J.
    Dongping, W.
    Zhiyong, G.
    Xiaoshun, H.
    TRANSPLANTATION PROCEEDINGS, 2018, 50 (01) : 202 - 210
  • [44] Preoperative autologous blood donation for kidney transplant and end-stage renal disease patients: A single-center study
    Kobayashi, Hirohito
    Konno, Mayumi
    Utsugisawa, Taiju
    Tanabe, Kazunari
    Kanno, Hitoshi
    TRANSFUSION AND APHERESIS SCIENCE, 2021, 60 (04)
  • [45] The evolution of lupus activity among patients with end-stage renal disease secondary to lupus nephritis
    Goo, YS
    Park, HC
    Choi, HY
    Kim, BS
    Park, YB
    Lee, SK
    Kang, SW
    Kim, SI
    Kim, YS
    Park, KI
    Lee, HY
    Han, DS
    Choi, KH
    YONSEI MEDICAL JOURNAL, 2004, 45 (02) : 199 - 206
  • [46] IS KIDNEY TRANSPLANTATION IN END-STAGE RENAL DISEASE PATIENTS OVER 75 A SAFE AND EFFECTIVE KIDNEY REPLACEMENT THERAPY?
    Gigante, Marc
    Mazzola, Clarisse
    Lefrancois, Nicole
    Tillou, Xavier
    Neuzillet, Yann
    TRANSPLANT INTERNATIONAL, 2012, 25 : 49 - 49
  • [47] DEVELOPMENT OF END-STAGE RENAL DISEASE IN KIDNEY DONORS: A SINGLE-INSTITUTION EXPERIENCE
    Greco, Kristin A.
    Farooq, Ahmer V.
    Holt, David
    Hou, Susan
    Milner, John E.
    JOURNAL OF UROLOGY, 2009, 181 (04): : 739 - 739
  • [48] Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States
    Devlin, Amy
    Waikar, Sushrut
    Solomon, Daniel H.
    Lu, Bing
    Shaykevich, Tamara
    Alarcon, Graciela S.
    Winkelmayer, Wolfgang C.
    Costenbader, Karen H.
    ARTHRITIS CARE & RESEARCH, 2011, 63 (12) : 1642 - 1653
  • [49] The incidence of end-stage renal failure in 17 years of heart transplantation: A single center experience
    Satchithananda, DK
    Parameshwar, J
    Sharples, L
    Taylor, GJ
    McNeil, K
    Wallwork, J
    Large, SR
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2002, 21 (06): : 651 - 657
  • [50] End-stage renal disease in lupus: Disease activity, dialysis, and the outcome of transplantation
    Stone, JH
    LUPUS, 1998, 7 (09) : 654 - 659