Analytical High-resolution Electron Microscopy Reveals Organ-specific Nanoceria Bioprocessing

被引：18

作者：

Graham, Uschi M. ^{[1
,2
]}

Yokel, Robert A. ^{[1
]}

Dozier, Alan K. ^{[2
]}

Drummy, Lawrence ^{[3
]}

Mahalingam, Krishnamurthy ^{[3
]}

Tseng, Michael T. ^{[4
]}

Birch, Eileen ^{[2
]}

Fernback, Joseph ^{[2
]}

机构：

[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, 1525 Bull Lea Rd,Ste 10, Lexington, KY 40515 USA

[2] NIOSH, Cincinnati, OH 45226 USA

[3] US Air Force Res Lab, Dayton, OH USA

[4] Univ Louisville, Coll Med, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA

来源：

TOXICOLOGIC PATHOLOGY | 2018年 / 46卷 / 01期

基金：

美国国家环境保护局; 美国国家卫生研究院;

关键词：

bioprocessing; ions; liver; nanoceria; nanoparticles; spleen; transformation; CERIUM OXIDE NANOPARTICLES; OXIDATIVE STRESS; BIOMEDICAL APPLICATIONS; PROTECT; RATS; MECHANISMS; BIODEGRADATION; BIOPERSISTENCE; NANOMATERIALS; HYPERTENSION;

D O I：

10.1177/0192623317737254

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This is the first utilization of advanced analytical electron microscopy methods, including high-resolution transmission electron microscopy, high-angle annular dark field scanning transmission electron microscopy, electron energy loss spectroscopy, and energy-dispersive X-ray spectroscopy mapping to characterize the organ-specific bioprocessing of a relatively inert nanomaterial (nanoceria). Liver and spleen samples from rats given a single intravenous infusion of nanoceria were obtained after prolonged (90 days) in vivo exposure. These advanced analytical electron microscopy methods were applied to elucidate the organ-specific cellular and subcellular fate of nanoceria after its uptake. Nanoceria is bioprocessed differently in the spleen than in the liver.

引用

页码：47 / 61

页数：15

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