MICROBIAL HYDROXYLATION OF SOME STEROIDS BY Aspergillus wentii MRC 200316

被引：10
|
作者：
Yildirim, Kudret [1 ]
机构：
[1] Sakarya Univ, Dept Chem, TR-54187 Sakarya, Turkey
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2010年 / 75卷 / 12期
关键词：
Steroids; Biotransformation; Hydroxylation; Aspergillus wentii; OCCURRING NITRO-COMPOUND; CEPHALOSPORIUM-APHIDICOLA; TOXIC METABOLITE; BIOTRANSFORMATION; IDENTIFICATION; PROGESTERONE; TESTOSTERONE; SPECTROMETRY; DERIVATIVES; SPECTRA;
D O I：
10.1135/cccc2010112
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biotransformations of epiandrosterone (1), dehydroepiandrosterone (2) and pregnenolone (3) by Aspergillus wentii MRC 200316 for 5 days have been reported. Incubation of epiandrosterone (1) afforded 11 alpha-hydroxy-5 alpha-androstane-3,17-dione (4) and 3 beta,11 alpha-dihydroxy-5 alpha- androstan-17-one (5). Incubation of dehydroepiandrosterone (2) afforded 3 beta,7 alpha-dihydroxyandrost-5-en-17-one (6) and 3 beta,7 alpha-dihydroxyandrost-5-en-17-one (7). Incubation of pregnenolone (3) afforded only 11 alpha-hydroxypregn-4-ene-3,20-dione (8).
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页码：1273 / 1281
页数：9
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