Synthesis, structural characterization, DNA/protein binding and antioxidant activities of binuclear Ni(II) complexes containing ONS chelating ligands bridged by 1,3-bis(diphenylphosphino)propane

被引：20
|
作者：
Kalaiarasi, G. [1 ]
Dharani, S. [1 ]
Puschmann, H. [2 ]
Prabhakaran, R. [1 ]
机构：
[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India
[2] Univ Durham, Dept Chem, Durham DH1 3LE, England
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2018年 / 97卷
关键词：
ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; PROTEIN-BINDING; THIOSEMICARBAZONE LIGANDS; NICKEL(II) COMPLEXES; CRYSTAL-STRUCTURES; DNA CLEAVAGE; CYTOTOXICITY; CRYSTALLOGRAPHY; SUBSTITUTION;
D O I：
10.1016/j.inoche.2018.09.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Binuclear Ni(II) complexes of 4-diethylaminosalicylaldehyde-4(N)-substituted thiosemicarbazones bridged by 1,3-bis(diphenylphosphino)propane have been synthesized and characterized. A spectroscopic evaluation of their binding ability with DNA and protein was carried out, the results of which implied a better affinity for the complexes. The free radical scavenging activity of the complexes was found to be greater than those observed for the ligands, the metal precursor and standard Vitamin C.
引用
收藏
页码：34 / 38
页数：5
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